ArticleScientific reports2023
β-endorphin suppresses ultraviolet B irradiation-induced epidermal barrier damage by regulating inflammation-dependent mTORC1 signaling.
Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- HomologousMaterials today. Bio · 2026Article
- Neoagarotetraose from Marine Red Algae Ameliorates UVB-Induced Skin Barrier Damage in Mice and HaCaT Keratinocytes.Marine biotechnology (New York, N.Y.) · 2026Article
- Protective effects of Passiflora edulis Sims peel fermentation polysaccharide against UVB-induced photodamage via antioxidant and anti-inflammatory activities.Bioresources and bioprocessing · 2026Article
- The Anti-inflammatory, Antioxidant Effects and Protective Barrier Function of Cell-Free Supernatant of Potential Probiotic Staphylococcus epidermidis CCSM0322 in HaCaT Cell Induced by UVB.Probiotics and antimicrobial proteins · 2026Article
- Compound K suppresses epidermal aging induced by IL-17A treatment and UVB irradiation.Journal of ginseng research · 2025Article
- Article
- Nootkatone (NK), a grapefruit-derived sesquiterpenoid, suppresses UVB-induced damage by regulating NRF2-HO-1 and AhR-CYP1A1 signaling pathways in HaCaT cells.Food science and biotechnology · 2025Article
- Exploring the Active Constituents ofAntioxidants (Basel, Switzerland) · 2025Article
- Advances in plant essential oils and drug delivery systems for skincare.Frontiers in pharmacology · 2025Review
- Ultraviolet (UV) radiation: a double-edged sword in cancer development and therapy.Molecular biomedicine · 2024Review
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Authors and funding
5 authors.
Funding
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Abstract
Solar ultraviolet B (UVB) radiation triggers excessive inflammation, disrupting the epidermal barrier, and can eventually cause skin cancer. A previous study reported that under UVB irradiation, epidermal keratinocytes synthesize the proopiomelanocortin-derived peptide β-endorphin, which is known for its analgesic effect. However, little is known about the role of β-endorphin in UVB-exposed skin. Therefore, in this study, we aimed to explore the protective role of β-endorphin against UVB irradiation-induced damage to the skin barrier in normal human keratinocytes (NHKs) and on a human skin equivalent model. Treatment with β-endorphin reduced inflammatory responses in UVB-irradiated NHKs by inactivating the NF-κB signaling pathway. Additionally, we found that β-endorphin treatment reversed UVB-induced abnormal epidermal proliferation and differentiation in NHKs and, thus, repaired the skin barrier in UVB-treated skin equivalents. The observed effects of β-endorphin on UVB-irradiated NHKs were mediated via blockade of the Akt/mTOR signaling pathway. These results reveal that β-endorphin might be useful against UVB-induced skin injury, including the disruption of the skin barrier function.
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