Evidence map›Paper›PMID 38102167›Full record

ArticleScientific reports2023

The effect of donor against recipient one-way HLA mismatch on liver transplantation outcomes from a multicenter registry analysis.

Sunghae Park, Young Rok Choi, Dong Jin Joo, Young Kyoung You, Bong-Wan Kim, Yang Won Nah, Jai Young Cho, Tae-Seok Kim, Geun Hong, Man Ki Ju and 8 more

Open access · goldAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 15 institutions in 2 countries.

Sunghae ParkDepartment of Surgery, Samsung Medical Center, Sungkyunkwan University, School of Medicine, 50 Irwon-Dong, Gangnam-gu, Seoul, 135-710, Korea.
Young Rok ChoiDepartment of Surgery, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Korea.
Dong Jin JooDepartment of Surgery, Yonsei University College of Medicine, Seoul, Korea.
Young Kyoung YouDepartment of Surgery, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Bong-Wan KimDepartment of Liver Transplantation and Hepatobiliary Surgery, Ajou University School of Medicine, Suwon, Korea.
Yang Won NahDepartment of Surgery, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Korea.
Jai Young ChoDepartment of Surgery, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seoul, Korea.
Tae-Seok KimDepartment of Surgery, Dongsan Medical Center, Keimyung University School of Medicine, Daegu, Korea.
Geun HongDepartment of Surgery, Ewha Womans University Medical College, Seoul, Korea.
Man Ki JuDepartment of Surgery, Yonsei University Gangnam Severance Hospital, Seoul, Korea.
Suk-Won SuhDepartment of Surgery, College of Medicine, Chung-Ang University, Seoul, Korea.
Jae Do YangDepartment of Surgery, Jeonbuk National University Hospital, Jeonju, Korea.
Pyoung Jae ParkDepartment of Surgery, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Korea.
Jaehong JeongDepartment of Surgery, School of Medicine, Soonchunhyang University, Bucheon, Korea.
Ju Ik MoonDepartment of Surgery, Konyang University Hospital, Daejeon, Korea.
Dong-Sik KimDepartment of Surgery, Korea University College of Medicine, Seoul, Korea. kimds1@korea.ac.kr.ORCID 0000-0002-0608-1580
Jinsoo RhuDepartment of Surgery, Samsung Medical Center, Sungkyunkwan University, School of Medicine, 50 Irwon-Dong, Gangnam-gu, Seoul, 135-710, Korea. jsrrules@gmail.com.ORCID 0000-0001-9809-8525
Korean Organ Transplantation Registry Study Group
Samsung Medical Center · KRYonsei University · KRAjou University · KRCatholic University of Korea · KRChung-Ang University · KREwha Womans University Medical Center · KRJeonbuk National University Hospital · KRKeimyung University Dongsan Medical Center · KRKonyang University Hospital · KRKorea University · KRKorea University Medical Center · KRSeoul National University Bundang Hospital · KRSeoul National University Hospital · KRSoonchunhyang University · KRUlsan College · KR

Funding

Korea Centers for Disease Control and Prevention,South Korea 2014-ER6301-00Korea Centers for Disease Control and Prevention,South Korea 2014-ER6301-01Korea Centers for Disease Control and Prevention,South Korea 2014-ER6301-02Korea Centers for Disease Control and Prevention,South Korea 2017-ER6301-00Korea Centers for Disease Control and Prevention,South Korea 2017-ER6301-01Korea Centers for Disease Control and Prevention,South Korea 2017-ER6301-02Korea Centers for Disease Control and Prevention,South Korea 2020-ER7201-00
6 · The paper itself

Abstract

Donor against recipient one-way Human leukocyte antigen (HLA) mismatch (D → R one-way HLA MM) seemed strongly associated with graft-versus-host disease (GVHD). The aim of this study is to investigate the relevance of D → R one-way HLA MM in outcome of liver transplantation (LT). We retrospectively analyzed 2670 patients in Korean Organ Transplantation Registry database between April 2014 and December 2020. The patients were categorized into two groups whether D → R one-way HLA MM or not and evaluated the outcomes of LT between the two groups. 18 patients were found to be D → R one-way HLA MM. The incidence of GVHD (0.3% vs. 22.2%, p < 0.001) and mortality rate (11.6% vs. 38.9%, p = 0.003) was much higher in D → R one-way HLA MM group. D → R one-way HLA MM at 3 loci was seemed to be strongly associated with the incidence of GVHD (OR 163.3, p < 0.001), and found to be the strongest risk factor for patient death (HR 12.75, p < 0.001). Patients with D → R one-way HLA MM at 3 loci showed significantly lower overall survival (p < 0.001) but there were no significant differences in rejection-free survival and death-censored graft survival. D → R one-way HLA MM at 3 loci not only affects the overall survival of LT patients but also the incidence of GVHD.

Indexed as

Graft vs Host DiseaseLiver TransplantationHistocompatibility Antigens Class IHistocompatibility Antigens Class IIHistocompatibility TestingHLA AntigensHumansRetrospective StudiesHistocompatibility Antigens Class IHistocompatibility Antigens Class IIHLA Antigens

Identifiers

PMID38102167
PMCPMC10724161
OpenAlexW4389791747

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.