ArticleNature communications2023
Tandem gene duplications contributed to high-level azole resistance in a rapidly expanding Candida tropicalis population.
Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 30 papers.
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30 citing papers in PubMed, 38 citations in OpenAlex.
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- From Oral Candidiasis to Candidemia: A Review of Superficial to Invasive Progression.MicrobiologyOpen · 2026Review
- Genomic insights into a clade-specificmBio · 2026Article
- Persistence and spread of fluconazole-resistantMicrobial genomics · 2026Article
- Yeast infections in sterile body fluids: species distribution, antifungal susceptibility, and cross-cutting risk factors for fungemia, sepsis, and mortality (2019-2023).Frontiers in microbiology · 2026Article
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- Clinical Characteristics and Risk Factors for Mortality in Candidemia: A Retrospective Single-Center Study in China.Infection and drug resistance · 2026Article
- Genomic epidemiology and antifungal resistance of emergingEmerging microbes & infections · 2025Article
- Genome analysis and machine learning-based feature selection strategy reveal potential drug-resistance determinants inEmerging microbes & infections · 2025Article
- Retrospective Multicenter Study on Invasive Candidiasis in Türkiye Demonstrates High Genetic Variety of Candida tropicalis.Mycopathologia · 2025Article
- The First Isolation of Multiple Antifungal-Drug-Resistant Trichophyton Rubrum in China and the Novel Resistance Mechanism.Mycoses · 2025Article
- Genomic Insights into Azole Resistance Mechanisms in Candida tropicalis Among Hematological Malignancy Patients with Candidemia.Current microbiology · 2025Article
- Epidemiology, risk factors, and antifungal susceptibility analysis of Candida tropicalis and non-C.tropicalis candidemia.BMC infectious diseases · 2025Article
- Clinical and Molecular Epidemiological Characteristics of 26 Bloodstream Infection Cases Caused by Candida tropicalis.Mycopathologia · 2025Article
- Emergence of Flucytosine-Resistant Candida tropicalis Clade, the Netherlands.Emerging infectious diseases · 2025Article
- Adaptive morphological changes link to poor clinical outcomes by conferring echinocandin tolerance in Candida tropicalis.PLoS pathogens · 2025Article
- An agricultural triazole induces genomic instability and haploid cell formation in the human fungal pathogen Candida tropicalis.PLoS biology · 2025Article
- Article
Corrections and comments
- Erratum issued
Authors and funding
12 authors at 9 institutions in 1 country.
Funding
Abstract
Invasive diseases caused by the globally distributed commensal yeast Candida tropicalis are associated with mortality rates of greater than 50%. Notable increases of azole resistance have been observed in this species, particularly within Asia-Pacific regions. Here, we carried out a genetic population study on 1571 global C. tropicalis isolates using multilocus sequence typing (MLST). In addition, whole-genome sequencing (WGS) analysis was conducted on 629 of these strains, comprising 448 clinical invasive strains obtained in this study and 181 genomes sourced from public databases. We found that MLST clade 4 is the predominant azole-resistant clone. WGS analyses demonstrated that dramatically increasing rates of azole resistance are associated with a rapid expansion of cluster AZR, a sublineage of clade 4. Cluster AZR isolates exhibited a distinct high-level azole resistance, which was induced by tandem duplications of the ERG11
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