ArticleNature communications2023
Identification of 5-HT
Open access · goldAbstract read
In one paragraph
Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 103 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
103citing papers in PubMed, 3 pooled it
41.7field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
103 citing papers in PubMed, 3 syntheses or guidelines pooled it, 133 citations in OpenAlex.
- A systematic review of the pharmacokinetics of classical serotonergic psychedelic compounds in healthy adult subjects.Journal of psychopharmacology (Oxford, England) · 2026Pooled it
- Therapeutic Use of Psilocybin in Depression: a Systematic Review of Clinical Evidence.Acta neuropsychiatrica · 2025Pooled it
- Synergistic, multi-level understanding of psychedelics: three systematic reviews and meta-analyses of their pharmacology, neuroimaging and phenomenology.Translational psychiatry · 2024Pooled it
- Psychedelics and disorders of consciousness: a new frontier in neurotherapeutics.Molecular psychiatry · 2026Review
- Moving beyond 5-HTPsychopharmacology · 2026Article
- Deconstruction of lysergic acid diethylamide.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Mechanistic Basis for 5-HTNature communications · 2026Article
- Review
- The Emergence of Isotryptamine Analogs as Novel Serotonergic Agents with Psychotherapeutic Potential.ACS pharmacology & translational science · 2026Review
- Psilocybin enhances sociability only in altered behavioural state and does not need an awake experience to be effective.Nature communications · 2026Article
- Role of β-Arrestin2 Signaling in Neuropharmacological Effects of Psychedelic Drugs.ACS chemical neuroscience · 2026Article
- Serotonergic psychedelics induce distinct patterns of metabolic activity and covariance within biologically informed rat brain networks.Nature communications · 2026Article
- In-silico toxicity study of tryptamine, psilocin, psilocybin, N,N-dimethyltryptamine, 5'-methoxy-N,N-dimethyltryptamine and O-acetylpsilocin.Archives of toxicology · 2026Article
- Classic Psychedelics for Treating Chronic Pain: Mechanism and Clinical Translation.Molecules (Basel, Switzerland) · 2026Review
- Psilocybin restores behavior and 5-HTCell reports. Medicine · 2026Article
- Integrated 5-HTMolecular psychiatry · 2026Article
- The working lives of neuronal 5-HTRSC chemical biology · 2026Review
- Synthesis and Biological Evaluation of 4‑Bromo-ACS omega · 2026Article
- Naturally Derived Psilocybin for Therapeutic Use: A Six-Criterion Framework for Evidence, Safety, and Benefit-Risk Considerations in Policy and Clinical Development.Biomolecules · 2026Review
- No evidence for direct physical interaction of 5-HTbioRxiv : the preprint server for biology · 2026Article
43 more citing papers are in PubMed but not listed here.
Corrections and comments
- Update of
Authors and funding
19 authors at 8 institutions in 3 countries.
Jason WallachDepartment of Pharmaceutical Sciences, Saint Joseph's University, Philadelphia, PA, 19104, USA. jwallach@sju.edu.
Andrew B CaoDepartment of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, WI, 53226, USA.
Maggie M CalkinsDepartment of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, WI, 53226, USA.ORCID 0000-0001-5639-0739
Andrew J HeimDepartment of Chemistry, Saint Joseph's University, Philadelphia, PA, 19104, USA.ORCID 0009-0003-6520-3810
Janelle K LanhamDepartment of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, WI, 53226, USA.ORCID 0000-0002-0603-4581
Emma M BonniwellDepartment of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, WI, 53226, USA.ORCID 0000-0001-5743-852X
Joseph J HennesseyDepartment of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, WI, 53226, USA.
Hailey A BockDepartment of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, WI, 53226, USA.ORCID 0000-0002-3457-9319
Emilie I AndersonDepartment of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, WI, 53226, USA.
Alexander M SherwoodUsona Institute, Madison, WI, 53711, USA.
Hamilton MorrisDepartment of Pharmaceutical Sciences, Saint Joseph's University, Philadelphia, PA, 19104, USA.
Robbin de KleinResearch Service, VA San Diego Healthcare System, San Diego, CA, 92161, USA.
Adam K KleinDepartment of Psychiatry, University of California San Diego, La Jolla, CA, 92093, USA.ORCID 0000-0002-1640-9324
Bruna CuccurazzuDepartment of Psychiatry, University of California San Diego, La Jolla, CA, 92093, USA.ORCID 0009-0003-2517-2546
James GamratDepartment of Pharmaceutical Sciences, Saint Joseph's University, Philadelphia, PA, 19104, USA.
Tilka FannanaDepartment of Pharmaceutical Sciences, Saint Joseph's University, Philadelphia, PA, 19104, USA.
Randy ZauharDepartment of Chemistry, Saint Joseph's University, Philadelphia, PA, 19104, USA.
Adam L HalberstadtResearch Service, VA San Diego Healthcare System, San Diego, CA, 92161, USA. ahalberstadt@health.ucsd.edu.
John D McCorvyDepartment of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, WI, 53226, USA. jmccorvy@mcw.edu.ORCID 0000-0001-7555-9413
Medical College of Wisconsin · USSaint Joseph's University · USUniversity of California San Diego · USAstrophysique Relativiste, Théories, Expériences, Métrologie, Instrumentation, Signaux · FRUC San Diego Health System · USUniversité de Sherbrooke · CAUsona Institute · USVA San Diego Healthcare System · US
Funding
Molecular Mechanisms of G protein-coupled Receptor Biased SignalingR35GM133421 · NIGMS · MEDICAL COLLEGE OF WISCONSIN · PI John D McCorvy · 2019 to 2026
$3.3MThe Next Generation of Hallucinogens: A New Class of Synthetic Psychoactive DrugsR01DA041336 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI HALBERSTADT, ADAM L. · 2017 to 2020
$1.4MNIDA NIH HHS R01 DA041336NIGMS NIH HHS R35 GM133421
Abstract
Serotonergic psychedelics possess considerable therapeutic potential. Although 5-HT
Indexed as
HallucinogensAnimalsbeta-ArrestinsLigandsMaleMiceReceptor, Serotonin, 5-HT2ASerotoninSignal Transductionbeta-ArrestinsHallucinogensLigandsReceptor, Serotonin, 5-HT2ASerotonin
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.