Evidence map›Paper›PMID 38102001›Full record

ReviewCytokine & growth factor reviews2024

Harnessing the potential of CD40 agonism in cancer therapy.

Yang Zhou, Ann Richmond, Chi Yan

Open access · greenAbstract readReview
In one paragraph

Review in Cytokine & growth factor reviews, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
6.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 40 citations in OpenAlex.

  1. B cells in cancer: functions, mechanisms and therapeutic advances.Signal transduction and targeted therapy · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Yang ZhouTennessee Valley Healthcare System, Department of Veteran Affairs, Nashville, TN, USA; Vanderbilt University School of Medicine, Department of Pharmacology, Nashville, TN, USA.
Ann RichmondTennessee Valley Healthcare System, Department of Veteran Affairs, Nashville, TN, USA; Vanderbilt University School of Medicine, Department of Pharmacology, Nashville, TN, USA.
Chi YanTennessee Valley Healthcare System, Department of Veteran Affairs, Nashville, TN, USA; Vanderbilt University School of Medicine, Department of Pharmacology, Nashville, TN, USA. Electronic address: chi.yan@vanderbilt.edu.
Vanderbilt University · US

Funding

Targeting the NF-kappaB Pathway in MelanomaR01CA116021 · NCI · VANDERBILT UNIVERSITY · PI RICHMOND, ANN, YAN, CHI · 2005 to 2024
$6.7M
Optimizing Response to Immune Checkpoint Inhibitor Therapy for Breast Cancer: A Role for Inhibitors of the PI3K pathwayR01CA243326 · NCI · VANDERBILT UNIVERSITY · PI RICHMOND, ANN, YAN, CHI · 2020 to 2024
$1.8M
Modeling New Therapeutic Approaches for Malignant MelanomaI01BX002301 · VA · VETERANS HEALTH ADMINISTRATION · PI Julie A Rhoades (Sterling) · 2014 to 2026
–
BLR&D Merit Review Research Career Scientist (RCS) Award (IK6)IK6BX005225 · VA · VETERANS HEALTH ADMINISTRATION · PI RICHMOND, ANN · 2020 to 2023
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BLRD VA I01 BX002301BLRD VA IK6 BX005225NCI NIH HHS R01 CA116021NCI NIH HHS R01 CA243326
6 · The paper itself

Abstract

CD40 is a member of the tumor necrosis factor (TNF) receptor superfamily of receptors expressed on a variety of cell types. The CD40-CD40L interaction gives rise to many immune events, including the licensing of dendritic cells to activate CD8

Indexed as

CD40 AntigensNeoplasmsCD40 LigandCytokinesHumansT-LymphocytesCD40 AntigensCD40 LigandCytokinesAgonistic antibodiesCancerCD40Molecular mechanismToxicity

Identifiers

PMID38102001
PMCPMC10922420
OpenAlexW4389298130

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.