ArticleBeijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences2023
[Predictive value of four items of new thrombus markers combined with conventional coagulation tests for thrombosis in antiphospholipid syndrome].
Article in Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed, 2 citations in OpenAlex.
- Risk factors and clinical strategies for lower extremity deep vein thrombosis following breast cancer surgery.American journal of translational research · 2026Article
- Clinical characteristics of patients with acute pulmonary embolism complicated with antiphospholipid syndrome: a case control study.BMC pulmonary medicine · 2025Article
- Elevated thrombosis-related biomarkers as predictors of disease severity and mortality in patients with severe fever with thrombocytopenia syndrome.BMC infectious diseases · 2025Article
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Authors and funding
6 authors at 2 institutions in 1 country.
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Abstract
objectiveTo explore the predictive value of four items of new thrombus markers combined with conventional coagulation tests for thrombosis in antiphospholipid syndrome.
methodsA total of 121 antiphospholipid syndrome (APS) patients who hospitalized at Peking University People's Hospital from March 2022 to January 2023 were selected and divided into thrombus group (50 cases) and nonthrombus group (71 cases) according to whether thrombosis occurred. The differences of laboratory characteristics including antiphospholipid antibodies were compared between the thrombotic and non-thrombotic groups. Chemiluminescent immunoassay was used to detect thrombomodulin (TM), thrombin-antithrombin complex (TAT), Plasmin-α2 plasmin inhibitor complex (PIC), and tissue plasminogen activator inhibitor complex (t-PAIC) in plasma from venous. The independent risk factors of thrombosis in patients with APS were determined using binary Logistic regression. Receiver operating characteristic (ROC) curve analysis was applied to evaluate the efficacy of each index on the prediction of thrombosis.
resultsCompared with the patients without thrombosis, the patients with thrombosis were older [49 (32, 64) years
conclusionTAT, PIC, TM, and t-PAIC may reflect thrombus formation from the coagulation system, fibrinolysis system, and endothelial system. The combined of age TM and PT is superior to the application of a single marker, which has diagnostic value for the early identification of APS thrombosis.
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38101785PMC10723993W4389836866What OpenQuestion holds
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