Evidence map›Paper›PMID 38101777›Full record

ArticleBeijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences2023

[Interferon-α mediating the functional damage of CD56

Xiang Ge Zhao, Jia Qing Liu, Hui Na Huang, Zhi Min Lu, Zi Ran Bai, Xia Li, Jing Jing Qi

Abstract readEnglish Abstract
PubMed Full text at PMC
In one paragraph

Article in Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xiang Ge ZhaoDepartment of Immunology, College of Basic Medical Science, Dalian Medical University, Dalian 116044, Liaoning, China.
Jia Qing LiuDepartment of Immunology, College of Basic Medical Science, Dalian Medical University, Dalian 116044, Liaoning, China.
Hui Na HuangDepartment of Immunology, College of Basic Medical Science, Dalian Medical University, Dalian 116044, Liaoning, China.
Zhi Min LuDepartment of Immunology, College of Basic Medical Science, Dalian Medical University, Dalian 116044, Liaoning, China.
Zi Ran BaiDepartment of Immunology, College of Basic Medical Science, Dalian Medical University, Dalian 116044, Liaoning, China.
Xia LiDepartment of Immunology, College of Basic Medical Science, Dalian Medical University, Dalian 116044, Liaoning, China.
Jing Jing QiDepartment of Immunology, College of Basic Medical Science, Dalian Medical University, Dalian 116044, Liaoning, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate the regulatory effect of interferon-α (IFN-α) on the apoptosis and killing function of CD56

methodsA total of sixty-four newly treated SLE patients and sixteen healthy controls (HC) enrolled in the Second Hospital of Dalian Medical University were selected as the research subjects. And the gene expression levels of molecules related to NK cell-killing function were detected by real-time quantitative polymerase chain reaction. CD56

resultsCompared with HC(

conclusionHigh serum IFN-α level in SLE patients may induce apoptosis by promoting mtROS production and inhibit perforin expression, which can down-regulate CD56

Indexed as

Interferon-alphaLupus Erythematosus, SystemicCD56 AntigenHumansHydrogen PeroxideInterferon-gammaKiller Cells, NaturalLeukocytes, MononuclearPerforinCD56 AntigenHydrogen PeroxideInterferon-alphaInterferon-gammaPerforinInterferon-αNatural killer cellsPerforinReactive oxygen speciesSystemic lupus erythematosus

Identifiers

PMID38101777
PMCPMC10723978

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.