Evidence map›Paper›PMID 38101593›Full record

ArticleAmerican journal of ophthalmology2024

FL-41 Tint Reduces Activation of Neural Pathways of Photophobia in Patients with Chronic Ocular Pain.

Nicholas Reyes, Jaxon J Huang, Anjalee Choudhury, Nicholas Pondelis, Elyana V T Locatelli, Ruby Hollinger, Elizabeth R Felix, Pradip M Pattany, Anat Galor, Eric A Moulton

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of ophthalmology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Nicholas ReyesSurgical Services, Miami Veterans Administration Medical Center (N.R., J.J.H., A.C., E.V.T.L., R.H., A.G.), Miami, Florida, USA; Bascom Palmer Eye Institute, University of Miami (N.R., J.J.H., A.C., E.V.T.L., A.G.), Miami, Florida, USA.
Jaxon J HuangSurgical Services, Miami Veterans Administration Medical Center (N.R., J.J.H., A.C., E.V.T.L., R.H., A.G.), Miami, Florida, USA; Bascom Palmer Eye Institute, University of Miami (N.R., J.J.H., A.C., E.V.T.L., A.G.), Miami, Florida, USA.
Anjalee ChoudhurySurgical Services, Miami Veterans Administration Medical Center (N.R., J.J.H., A.C., E.V.T.L., R.H., A.G.), Miami, Florida, USA; Bascom Palmer Eye Institute, University of Miami (N.R., J.J.H., A.C., E.V.T.L., A.G.), Miami, Florida, USA.
Nicholas PondelisBrain and Eye Pain Imaging Lab, Pain and Affective Neuroscience Center, Department of Anesthesia (N.P., E.A.M.), Critical Care and Pain Medicine, Boston Children's Hospital, Harvard Medical School, Massachusetts, USA.
Elyana V T LocatelliSurgical Services, Miami Veterans Administration Medical Center (N.R., J.J.H., A.C., E.V.T.L., R.H., A.G.), Miami, Florida, USA; Bascom Palmer Eye Institute, University of Miami (N.R., J.J.H., A.C., E.V.T.L., A.G.), Miami, Florida, USA.
Ruby HollingerSurgical Services, Miami Veterans Administration Medical Center (N.R., J.J.H., A.C., E.V.T.L., R.H., A.G.), Miami, Florida, USA.
Elizabeth R FelixResearch Service, Miami Veterans Administration Medical Center (E.R.F.), Miami, Florida, USA; Physical Medicine and Rehabilitation (E.R.F.), University of Miami, Miami, Florida, USA.
Pradip M PattanyDepartment of Radiology (P.M.P.), University of Miami, Miami, Florida, USA.
Anat GalorSurgical Services, Miami Veterans Administration Medical Center (N.R., J.J.H., A.C., E.V.T.L., R.H., A.G.), Miami, Florida, USA; Bascom Palmer Eye Institute, University of Miami (N.R., J.J.H., A.C., E.V.T.L., A.G.), Miami, Florida, USA.
Eric A MoultonBrain and Eye Pain Imaging Lab, Pain and Affective Neuroscience Center, Department of Anesthesia (N.P., E.A.M.), Critical Care and Pain Medicine, Boston Children's Hospital, Harvard Medical School, Massachusetts, USA; Department of Ophthalmology (E.A.M.), Boston Children's Hospital, Harvard Medical School, Massachusetts, USA. Electronic address: eric.moulton@childrens.harvard.edu.
United States Department of Veterans Affairs · USBoston Children's Hospital · USUniversity of Miami · US

Funding

Shared Equipment ModuleP30EY014801 · NEI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Victor L Perez · 2004 to 2026
$12.2M
Differentiation of Clinical Phenotypes of Inflammatory and Neuropathic Ocular Pain Conditions with Morphologic Measures and Functional Brain ImagingU01EY034686 · NEI · BOSTON CHILDREN'S HOSPITAL · PI Eric Alan Moulton · 2022 to 2026
$4.7M
Tear protein biomarkers of refractive surgery painR61EY032468 · NEI · OREGON HEALTH & SCIENCE UNIVERSITY · PI AICHER, SUE A, GALOR, ANAT · 2020 to 2022
$2.0M
Dry Eye and MicroenvironmentR01EY026174 · NEI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI GALOR, ANAT, KUMAR, NARESH · 2016 to 2020
$1.9M
The trigeminal nociceptive-pain pathway in pediatric mTBI: peripheral and central contributions to photophobiaR01EY034135 · NEI · BOSTON CHILDREN'S HOSPITAL · PI Scott Holmes, Eric Alan Moulton · 2023 to 2026
$1.9M
Lipid mediators and their signaling in ocular surface inflammation and meibomian gland dysfunctionI01BX004893 · VA · MIAMI VA HEALTH CARE SYSTEM · PI GALOR, ANAT, MANDAL, NAWAJES · 2021 to 2025
–
A pilot study of the safety and feasibility of transcutaneous electrical nerve stimulation (TENS) for chronic ocular painI21RX003883 · VA · MIAMI VA HEALTH CARE SYSTEM · PI FELIX, ELIZABETH ROY · 2022 to 2023
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Neural mechanisms underlying photophobia and dry eyeI01CX002015 · VA · MIAMI VA HEALTH CARE SYSTEM · PI Anat Galor · 2020 to 2026
–
BLRD VA I01 BX004893CSRD VA I01 CX002015NEI NIH HHS P30 EY014801NEI NIH HHS R01 EY026174NEI NIH HHS R01 EY034135NEI NIH HHS R61 EY032468NEI NIH HHS U01 EY034686RRD VA I21 RX003883
6 · The paper itself

Abstract

purposeTo assess the therapeutic effect of tinted lenses (FL-41) on photophobia and light-evoked brain activity using functional magnetic resonance imaging (fMRI) in individuals with chronic ocular surface pain.

designProspective case series.

methods25 subjects from the Miami veterans affairs (VA) eye clinic were recruited based on the presence of chronic ocular pain, dry eye symptoms, and photophobia. Using a 3T MRI scanner, subjects underwent 2 fMRI scans using an event-related design based on light stimuli: one scan while wearing FL-41 lenses and one without. Unpleasantness ratings evoked by the light stimuli were collected after each scan.

resultsWith FL-41 lenses, subjects reported decreased (n = 19), maintained (n = 2), or increased (n = 4) light-evoked unpleasantness ratings. Group analysis at baseline (no lens) revealed significant light evoked responses in bilateral primary somatosensory (S1), bilateral secondary somatosensory (S2), bilateral insula, bilateral frontal pole, visual, precuneus, paracingulate, and anterior cingulate cortices (ACC) as well as cerebellar vermis, bilateral cerebellar hemispheric lobule VI, and bilateral cerebellar crus I and II. With FL-41 lenses, light-evoked responses were significantly decreased in bilateral S1, bilateral S2, bilateral insular, right temporal pole, precuneus, ACC, and paracingulate cortices as well as bilateral cerebellar hemispheric lobule VI.

conclusionFL-41 lenses modulated photophobia symptoms in some individuals with chronic ocular pain. In conjunction, FL-41 lenses decreased activation in cortical areas involved in processing affective and sensory-discriminative dimensions of pain. Further research into these relationships will advance the ability to provide precision therapy for individuals with ocular pain.

Indexed as

PainPhotophobiaBrainEye PainHumansMagnetic Resonance ImagingNeural Pathways

Identifiers

PMID38101593
PMCPMC10939838
OpenAlexW4389737002

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.