Evidence map›Paper›PMID 38101469›Full record

ArticleBrain stimulation

Longitudinal resting-state network connectivity changes in electroconvulsive therapy patients compared to healthy controls.

Joey P A J Verdijk, Laurens A van de Mortel, Freek Ten Doesschate, Julia C M Pottkämper, Sven Stuiver, Willem B Bruin, Christopher C Abbott, Miklos Argyelan, Olga T Ousdal, Hauke Bartsch and 8 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain stimulation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Postictal resting-state connectivity changes after electroconvulsive therapy-induced seizures.European archives of psychiatry and clinical neuroscience · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Heart-Brain Interactions in Depression: Insights from HRV and Neurocognitive Correlates.Nigerian medical journal : journal of the Nigeria Medical Association
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Joey P A J VerdijkRijnstate Hospital, Department of Psychiatry, P.O. Box 9555, 6800 TA Arnhem, the Netherlands; University of Twente, Department of Clinical Neurophysiology, Enschede, the Netherlands. Electronic address: jverdijk@rijnstate.nl.
Laurens A van de MortelAmsterdam UMC location University of Amsterdam, Department of Psychiatry, Amsterdam, the Netherlands; Amsterdam Neuroscience, Amsterdam, the Netherlands.
Freek Ten DoesschateRijnstate Hospital, Department of Psychiatry, P.O. Box 9555, 6800 TA Arnhem, the Netherlands; Amsterdam UMC location University of Amsterdam, Department of Psychiatry, Amsterdam, the Netherlands; Amsterdam Neuroscience, Amsterdam, the Netherlands.
Julia C M PottkämperRijnstate Hospital, Department of Psychiatry, P.O. Box 9555, 6800 TA Arnhem, the Netherlands; University of Twente, Department of Clinical Neurophysiology, Enschede, the Netherlands.
Sven StuiverRijnstate Hospital, Department of Psychiatry, P.O. Box 9555, 6800 TA Arnhem, the Netherlands; University of Twente, Department of Clinical Neurophysiology, Enschede, the Netherlands.
Willem B BruinAmsterdam UMC location University of Amsterdam, Department of Psychiatry, Amsterdam, the Netherlands; Amsterdam Neuroscience, Amsterdam, the Netherlands.
Christopher C AbbottDepartment of Psychiatry, University of New Mexico School of Medicine, Albuquerque, NM, USA.
Miklos ArgyelanCenter for Psychiatric Neuroscience at the Feinstein Institute for Medical Research, New York, NY, USA.
Olga T OusdalDepartment of Biomedicine, University of Bergen, Bergen, Norway; Department of Radiology, Haukeland University Hospital, Bergen, Norway.
Hauke BartschDepartment of Computer Science, University of Bergen, Bergen, Norway; Mohn Medical Imaging and Visualization Center, Department of Radiology, Haukeland University Hospital, Bergen, Norway.
Katherine NarrDepartments of Neurology, Psychiatry, and Biobehavioral Sciences, University of California, Los Angeles, CA, USA.
Indira TendolkarDonders Institute for Brain, Cognition and Behavior, Department of Psychiatry, Nijmegen, the Netherlands.
Vince CalhounTri-institutional center for Translational Research in Neuroimaging and Data Science (TReNDS) Center, Emory University, USA.
Joshua LukemireEmory Center for Biomedical Imaging Statistics, Emory University, USA.
Ying GuoEmory Center for Biomedical Imaging Statistics, Emory University, USA.
Leif OltedalMohn Medical Imaging and Visualization Center, Department of Radiology, Haukeland University Hospital, Bergen, Norway.
Guido van WingenAmsterdam UMC location University of Amsterdam, Department of Psychiatry, Amsterdam, the Netherlands; Amsterdam Neuroscience, Amsterdam, the Netherlands.
Jeroen A van WaardeRijnstate Hospital, Department of Psychiatry, P.O. Box 9555, 6800 TA Arnhem, the Netherlands.

Funding

Statistical ICA Methods for Analysis & Integration of Multi-dimensional Data Diversity SupplementR01MH105561 · NIMH · EMORY UNIVERSITY · PI GUO, YING, KANG, JIAN · 2014 to 2024
$4.3M
Statistical Methods for Analyzing Complex, Multi-dimensional Data from Cross-sectional and Longitudinal Mental Health StudiesR01MH118771 · NIMH · EMORY UNIVERSITY · PI GUO, YING, MANATUNGA, AMITA K. · 2019 to 2023
$3.1M
NIMH NIH HHS R01 MH105561NIMH NIH HHS R01 MH118771
6 · The paper itself

Abstract

objectiveElectroconvulsive therapy (ECT) is effective for major depressive episodes. Understanding of underlying mechanisms has been increased by examining changes of brain connectivity but studies often do not correct for test-retest variability in healthy controls (HC). In this study, we investigated changes in resting-state networks after ECT in a multicenter study.

methodsFunctional resting-state magnetic resonance imaging data, acquired before start and within one week after ECT, from 90 depressed patients were analyzed, as well as longitudinal data of 24 HC. Group-information guided independent component analysis (GIG-ICA) was used to spatially restrict decomposition to twelve canonical resting-state networks. Selected networks of interest were the default mode network (DMN), salience network (SN), and left and right frontoparietal network (LFPN, and RFPN). Whole-brain voxel-wise analyses were used to assess group differences at baseline, group by time interactions, and correlations with treatment effectiveness. In addition, between-network connectivity and within-network strengths were computed.

resultsWithin-network strength of the DMN was lower at baseline in ECT patients which increased after ECT compared to HC, after which no differences were detected. At baseline, ECT patients showed lower whole-brain voxel-wise DMN connectivity in the precuneus. Increase of within-network strength of the LFPN was correlated with treatment effectiveness. We did not find whole-brain voxel-wise or between-network changes.

conclusionDMN within-network connectivity normalized after ECT. Within-network increase of the LFPN in ECT patients was correlated with higher treatment effectiveness. In contrast to earlier studies, we found no whole-brain voxel-wise changes, which highlights the necessity to account for test-retest effects.

Indexed as

Electroconvulsive TherapyMajor Depressive DisorderBrainBrain MappingHumansMagnetic Resonance ImagingParietal LobeBOLD imagingFunctional networksMajor depressive disorder

Identifiers

PMID38101469
PMCPMC11145948

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.