Evidence map›Paper›PMID 38100748›Full record

Trial reportLipids2023

Dietary linoleic acid lowering alone does not lower arachidonic acid or endocannabinoids among women with overweight and obesity: A randomized, controlled trial.

Amber B Courville, Sharon Majchrzak-Hong, Shanna Yang, Sara Turner, Breanne Wilhite, Katherine Ness Shipley, Yvonne Horneffer, Anthony F Domenichiello, Melanie Schwandt, Roy G Cutler and 3 more

Open access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Lipids, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Trial
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Amber B CourvilleNational Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland, USA.ORCID 0000-0002-1419-3937
Sharon Majchrzak-HongNational Institutes of Health, National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland, USA.
Shanna YangNational Institutes of Health, Clinical Center, Bethesda, Maryland, USA.
Sara TurnerNational Institutes of Health, Clinical Center, Bethesda, Maryland, USA.
Breanne WilhiteNational Institutes of Health, National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland, USA.
Katherine Ness ShipleyNational Institutes of Health, National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland, USA.
Yvonne HornefferNational Institutes of Health, National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland, USA.
Anthony F DomenichielloNational Institutes of Health, National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland, USA.ORCID 0000-0003-4808-8403
Melanie SchwandtNational Institutes of Health, National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland, USA.
Roy G CutlerNational Institutes of Health, National Institute on Aging, Bethesda, Maryland, USA.
Kong Y ChenNational Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland, USA.
Joseph R HibbelnNational Institutes of Health, National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland, USA.
Christopher E RamsdenNational Institutes of Health, National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland, USA.ORCID 0000-0002-4058-7630
National Institutes of Health · USNational Institutes of Health Clinical Center · US

Funding

Intramural NIH HHS Z99 DK999999NIAAA NIH HHSNIA NIH HHSNIDDK NIH HHS
6 · The paper itself

Abstract

The linoleic acid (LA)-arachidonic acid (ARA)-inflammatory axis suggests dietary LA lowering benefits health because it lowers ARA and ARA-derived endocannabinoids (ECB). Dietary LA reduction increases concentrations of omega-3 eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) and DHA derived ECB. The aim of this study was to examine targeted reduction of dietary LA, with and without EPA and DHA, on plasma EPA and DHA and ECB (2-arachidonoyl glycerol [2-AG], anandamide [AEA], and docosahexaenoyl ethanolamide [DHA-EA]). Healthy, pre-menopausal women (n = 62, BMI 30 ± 3 kg/m

Indexed as

EndocannabinoidsLinoleic AcidAdultArachidonic AcidArachidonic AcidsDietDocosahexaenoic AcidsEicosapentaenoic AcidFatty AcidsFemaleHumansObesityOverweightArachidonic AcidArachidonic AcidsDocosahexaenoic AcidsEicosapentaenoic AcidEndocannabinoidsFatty AcidsLinoleic Acidarachidonic aciddietdocosahexaenoic acideicosapentaeonic acidendocannabinoidlinoleic acid

Identifiers

PMID38100748
PMCPMC10767670
OpenAlexW4389779489

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.