Evidence map›Paper›PMID 38100716›Full record

ReviewJournal of agricultural and food chemistry2023

Molecular Targets of Herbicides and Fungicides─Are There Useful Overlaps for Fungicide Discovery?

Stephen O Duke, Zhiqiang Pan, Joanna Bajsa-Hirschel, Prabin Tamang, Raymond Hammerschmidt, Beth A Lorsbach, Thomas C Sparks

Open access · greenAbstract readReview
In one paragraph

Review in Journal of agricultural and food chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
13.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
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  5. Review
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  7. Transcriptome Analysis ofMicroorganisms · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Stephen O DukeNational Center for Natural Products Research, School of Pharmacy, University of Mississippi, University 38667, United States.ORCID 0000-0001-7210-5168
Zhiqiang PanNatural Products Utilization Research Unit, United States Department of Agriculture, University 38667, United States.
Joanna Bajsa-HirschelNatural Products Utilization Research Unit, United States Department of Agriculture, University 38667, United States.
Prabin TamangNatural Products Utilization Research Unit, United States Department of Agriculture, University 38667, United States.
Raymond HammerschmidtDepartment of Plant, Soil and Microbial Sciences, Michigan State University, East Lansing, Michigan 48824, United States.
Beth A LorsbachNufarm, 4020 Aerial Center Parkway, Morrisville, North Carolina 27560, United States.
Thomas C SparksAgrilucent LLC, Morro Bay, California 93442, United States.ORCID 0000-0002-0526-7594
United States Department of Agriculture · USMichigan State University · USUniversity of Mississippi · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

New fungicide modes of action are needed for fungicide resistance management strategies. Several commercial herbicide targets found in fungi that are not utilized by commercial fungicides are discussed as possible fungicide molecular targets. These are acetyl CoA carboxylase, acetolactate synthase, 5-enolpyruvylshikimate-3-phosphate synthase, glutamine synthase, phytoene desaturase, protoporphyrinogen oxidase, long-chain fatty acid synthase, dihydropteroate synthase, hydroxyphenyl pyruvate dioxygenase, and Ser/Thr protein phosphatase. Some of the inhibitors of these herbicide targets appear to be either good fungicides or good leads for new fungicides. For example, some acetolactate synthase and dihydropteroate inhibitors are excellent fungicides. There is evidence that some herbicides have indirect benefits to certain crops due to their effects on fungal crop pathogens. Using a pesticide with both herbicide and fungicide activities based on the same molecular target could reduce the total amount of pesticide used. The limitations of such a product are discussed.

Indexed as

Acetolactate SynthaseFungicides, IndustrialHerbicides3-Phosphoshikimate 1-CarboxyvinyltransferaseHerbicide ResistanceProtoporphyrinogen Oxidase3-Phosphoshikimate 1-CarboxyvinyltransferaseAcetolactate SynthaseFungicides, IndustrialHerbicidesProtoporphyrinogen Oxidasefungicideherbicidemode of actionmolecular targetplant pathologyweed

Identifiers

PMID38100716
PMCPMC10755756
OpenAlexW4389776104

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.