Evidence map›Paper›PMID 38100592›Full record

ArticleScience advances2023

Modularized microrobot with lock-and-detachable modules for targeted cell delivery in bile duct.

Lin Su, Dongdong Jin, Yuqiong Wang, Qinglong Wang, Chengfeng Pan, Shuai Jiang, Haojin Yang, Zhengxin Yang, Xin Wang, Neng Xia and 4 more

Abstract read
In one paragraph

Article in Science advances, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed.

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  18. A roadmap for next-generation nanomotors.Nature nanotechnology · 2025
    Review
  19. Review
  20. Magnetite Micro/Nanorobots for Efficient Targeted Alleviation of Inflammatory Bowel Disease.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Lin SuDepartment of Mechanical and Automation Engineering, The Chinese University of Hong Kong, Hong Kong SAR, China.ORCID 0000-0001-9970-7601
Dongdong JinSchool of Materials Science and Engineering, Harbin Institute of Technology (Shenzhen), Shenzhen, Guangdong 518055, China.ORCID 0000-0003-4833-538X
Yuqiong WangDepartment of Mechanical and Automation Engineering, The Chinese University of Hong Kong, Hong Kong SAR, China.
Qinglong WangDepartment of Mechanical and Automation Engineering, The Chinese University of Hong Kong, Hong Kong SAR, China.ORCID 0009-0008-4213-8506
Chengfeng PanDepartment of Mechanical and Automation Engineering, The Chinese University of Hong Kong, Hong Kong SAR, China.ORCID 0000-0001-8825-8011
Shuai JiangDepartment of Biomedical Engineering, The Chinese University of Hong Kong, Hong Kong SAR, China.ORCID 0000-0002-4524-5939
Haojin YangDepartment of Mechanical and Automation Engineering, The Chinese University of Hong Kong, Hong Kong SAR, China.
Zhengxin YangDepartment of Mechanical and Automation Engineering, The Chinese University of Hong Kong, Hong Kong SAR, China.ORCID 0000-0002-3160-0784
Xin WangDepartment of Mechanical and Automation Engineering, The Chinese University of Hong Kong, Hong Kong SAR, China.ORCID 0000-0002-2373-6139
Neng XiaDepartment of Mechanical and Automation Engineering, The Chinese University of Hong Kong, Hong Kong SAR, China.ORCID 0000-0001-6189-3138
Kai Fung ChanDepartment of Biomedical Engineering, The Chinese University of Hong Kong, Hong Kong SAR, China.ORCID 0000-0001-5820-0089
Philip Wai Yan ChiuMulti-Scale Medical Robotics Center, Hong Kong Science Park, Hong Kong SAR, China.ORCID 0000-0001-9292-112X
Joseph Jao-Yiu SungLee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.ORCID 0000-0003-3125-5199
Li ZhangDepartment of Mechanical and Automation Engineering, The Chinese University of Hong Kong, Hong Kong SAR, China.ORCID 0000-0003-1152-8962

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The magnetic microrobots promise benefits in minimally invasive cell-based therapy. However, they generally suffer from an inevitable compromise between their magnetic responsiveness and biomedical functions. Herein, we report a modularized microrobot consisting of magnetic actuation (MA) and cell scaffold (CS) modules. The MA module with strong magnetism and pH-responsive deformability and the CS module with cell loading-release capabilities were fabricated by three-dimensional printing technique. Subsequently, assembly of modules was performed by designing a shaft-hole structure and customizing their relative dimensions, which enabled magnetic navigation in complex environments, while not deteriorating the cellular functionalities. On-demand disassembly at targeted lesion was then realized to facilitate CS module delivery and retrieval of the MA module. Furthermore, the feasibility of proposed system was validated in an in vivo rabbit bile duct. Therefore, this work presents a modular design-based strategy that enables uncompromised fabrication of multifunctional microrobots and stimulates their development for future cell-based therapy.

Indexed as

Cell- and Tissue-Based TherapyDrug Delivery SystemsAnimalsPrinting, Three-DimensionalRabbits

Identifiers

PMID38100592
PMCPMC10848723

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.