Evidence map›Paper›PMID 38100467›Full record

ArticleJournal of veterinary internal medicine

Retrospective evaluation of hematological ratios in canine parvovirosis: 401 cases.

Andrea González-Domínguez, José Ignacio Cristobal-Verdejo, Clara López-Espinar, Sergio Fontela-González, Sergio Vázquez, Javier Justo-Domínguez, Jonatan González-Caramazana, Mónica Bragado-Cuesta, Alicia Álvarez-Punzano, Vicente J Herrería-Bustillo

Abstract readMulticenter Study
In one paragraph

Article in Journal of veterinary internal medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Sepsis in Dogs and Cats-Consensus Definition and Clinical Criteria.Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001)
    Pooled it
  2. Review
  3. Article
  4. Article
  5. Hematological Ratios inAnimals : an open access journal from MDPI · 2026
    Article
  6. Reference Intervals for Hematological Inflammatory Ratios in Healthy Dogs.Animals : an open access journal from MDPI · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Andrea González-DomínguezVeterinary Teaching Hospital of the Catholic University of Valencia-Emergency and critical care, Valencia, Spain.ORCID https://orcid.org/0009-0000-9304-4552
José Ignacio Cristobal-VerdejoUniversidad de Extremadura-Medicine Care, Badajoz, Extremadura, Spain.ORCID https://orcid.org/0000-0001-9015-7690
Clara López-EspinarUniversidad de Extremadura-Animal Medicine, Badajoz, Spain.
Sergio Fontela-GonzálezVeterinary Hospital Auna Especialidades-Emergency and Critical Care, Valencia, Spain.
Sergio VázquezServicio de Oncología, IVC Evidensia Aúna Especialidades Veterinarias, Valencia, Spain.ORCID https://orcid.org/0000-0003-4613-5747
Javier Justo-DomínguezVeterinary Hospital Puchol, Madrid, Spain.
Jonatan González-CaramazanaAniCura Valencia Sur Veterinary Hospital-Section of Neurology and Neurosurgery, Valencia, Spain.
Mónica Bragado-CuestaAniCura Valencia Sur Veterinary Hospital-Emergency and Critical Care, Valencia, Spain.
Alicia Álvarez-PunzanoVeterinary Teaching Hospital of the Alfonso X El Sabio-Emergency and Critical Care, Madrid, Spain.
Vicente J Herrería-BustilloVeterinary Teaching Hospital of the Catholic University of Valencia-Emergency and critical care, Valencia, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe utility of neutrophil-to-lymphocyte ratio (NLR), platelet to-lymphocyte ratio (PLR) and monocyte-to-lymphocyte ratio (MLR) as prognostic indicators has not been investigated in canine parvovirosis (CPV). HYPOTHESIS: To evaluate whether these hematological ratios obtained at hospital admission in CPV are associated with outcome or duration of hospitalization. ANIMALS: Four hundred one client-owned dogs presented with CPV. Methods-Retrospective multicenter cohort study. Medical records were reviewed to identify dogs with CPV. Data regarding signalment, complete blood count at admission, duration of hospitalization and outcome were collected.

resultsOf the 401 dogs included in the study, 336 (83.8%) survived to discharge. The median (25th and 75th percentiles) PLR in nonsurvivors (336.56 [159.84-635.77]) was significantly higher than in survivors (217.65 [117.67-389.65]) (P = .003). The area under the receiver-operating characteristic curve for nonsurvival was 0.615 (95% CI [0.593-0.691], P = .003). A cut off of 700 showed a 21.5% sensitivity and 90% specificity for nonsurvival. No association was observed between hospitalization duration and either hematological ratios or total WBC counts. The median (25th and 75th percentiles) lymphocyte count was below reference interval in all dogs and was significantly lower in the dogs which died (0.82 × 10

conclusionsEvaluation of PLR at hospital admission might be a useful marker of disease severity and could have prognostic value in dogs with CPV.

Indexed as

Blood PlateletsLymphocytesAnimalsCohort StudiesDogsHumansLeukocyte CountNeutrophilsPrognosisRetrospective Studiesbiomarkersclinical pathologyhematologymicrobiologymonocyte-to-lymphocyte rationeutrophil-to-lymphocyte ratioparvovirusplatelet functionplatelet-to-lymphocyte ratiosepsisvira

Identifiers

PMID38100467
PMCPMC10800196

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.