ArticleCell reports2023
Activity-dependent constraints on catecholamine signaling.
Article in Cell reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 21 citations in OpenAlex.
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- Meridian-sinew physical therapy modulates regional brain function and neurotransmitter spatial correlations in healthy volunteers: a neuroimaging study.Frontiers in human neuroscience · 2026Article
- Noradrenergic tuning of arousal is coupled to movement transitions.Cell reports · 2025Article
- Stimulus-Dependent Dopamine Dynamics from Locus Coeruleus Axons.bioRxiv : the preprint server for biology · 2025Article
- Adaptive arousal regulation: Pharmacologically shifting the peak of the Yerkes-Dodson curve by catecholaminergic enhancement of arousal.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Current knowledge on the pathophysiology of idiopathic hypersomnia and potential mechanisms of action for low-sodium oxybate treatment.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2025Review
- Dentate gyrus norepinephrine ramping facilitates aversive contextual processing.Nature communications · 2025Article
- The Mechanisms of Sepsis Induced Coagulation Dysfunction and Its Treatment.Journal of inflammation research · 2025Review
- Diversity of ancestral brainstem noradrenergic neurons across species and multiple biological factors.bioRxiv : the preprint server for biology · 2024Article
- Adrenergic C1 neurons enhance anxiety via projections to PAG.bioRxiv : the preprint server for biology · 2024Article
- Restoration of locus coeruleus noradrenergic transmission during sleep.bioRxiv : the preprint server for biology · 2024Article
- Non-invasive methods for analysing pig welfare biomarkers.Veterinarni medicina · 2024Review
- The effects of locus coeruleus optogenetic stimulation on global spatiotemporal patterns in rats.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Shining light on the noradrenergic system.Neurophotonics · 2023Review
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
Catecholamine signaling is thought to modulate cognition in an inverted-U relationship, but the mechanisms are unclear. We measured norepinephrine and dopamine release, postsynaptic calcium responses, and interactions between tonic and phasic firing modes under various stimuli and conditions. High tonic activity in vivo depleted catecholamine stores, desensitized postsynaptic responses, and decreased phasic transmission. Together, these findings provide a more complete understanding of the inverted-U relationship, offering insights into psychiatric disorders and neurodegenerative diseases with impaired catecholamine signaling.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.