Evidence map›Paper›PMID 38099637›Full record

ArticleThe journal of extra-corporeal technology2023

Central ECMO cannulation for severe dihydropyridine calcium channel blocker overdose.

Jose M Cardenas, Santiago Borasino, Joseph Timpa, Jeremy Hawkins, Martha McBride, William Rushton, Jordan Newman, Erika Mendoza, Robert Sorabella, Jonathan Byrnes

Open access · diamondAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in The journal of extra-corporeal technology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Calcium channel blocker overdose: Not all the same toxicity.British journal of clinical pharmacology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Jose M CardenasDivision of Pediatric Cardiology Section of Cardiac Critical Care. University of Alabama at Birmingham School of Medicine, Birmingham, AL, USA.ORCID 0000-0001-7354-3194
Santiago BorasinoDivision of Pediatric Cardiology Section of Cardiac Critical Care. University of Alabama at Birmingham School of Medicine, Birmingham, AL, USA.
Joseph TimpaECMO Clinical Coordinator Children's of Alabama, Birmingham, AL, USA.
Jeremy HawkinsDepartment of Cardiovascular Perfusion Children's of Alabama, Birmingham, AL, USA.
Martha McBrideECMO Clinical Coordinator Children's of Alabama, Birmingham, AL, USA.
William RushtonDepartment of Pediatric Emergency Medicine. University of Alabama at Birmingham School of Medicine, Birmingham, AL, USA.
Jordan NewmanDepartment of Pediatric Critical Care. University of Alabama at Birmingham School of Medicine, Birmingham, AL, USA.
Erika MendozaDivision of Pediatric Cardiology Section of Cardiac Critical Care. University of Alabama at Birmingham School of Medicine, Birmingham, AL, USA.
Robert SorabellaDivision of Pediatric Cardiology Section of Cardiac Critical Care. University of Alabama at Birmingham School of Medicine, Birmingham, AL, USA.
Jonathan ByrnesDivision of Pediatric Cardiology Section of Cardiac Critical Care. University of Alabama at Birmingham School of Medicine, Birmingham, AL, USA.
University of Alabama at Birmingham · USChildren's of Alabama · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Calcium channel blocker (CCB) toxicity carries a high mortality and is the sixth most fatal drug class reported to US poison centers. Amlodipine overdose is characterized by a life-threatening arterial vasodilation that compromises organ perfusion. The management of CCB intoxication is focused on maintaining adequate organ perfusion. In cases refractory to medical therapies, hemodynamic support with extracorporeal membrane oxygenation (ECMO) is warranted necessitating higher flows than usual to compensate for the vasodilation and requiring central cannulation. We present a case of a 12-year-old with severe dihydropyridine CCB ingestion, refractory to medical management and successfully treated with central ECMO cannulation. The patient was discharged home with no significant disability. Central ECMO cannulation may be helpful to facilitate adequate flows in vasodilatory shock such as CCB overdose.

Indexed as

DihydropyridinesExtracorporeal Membrane OxygenationCalcium Channel BlockersCatheterizationChildHumansPerfusionCalcium Channel BlockersDihydropyridinescardiovascularECMO (extracorporeal membrane oxygenation)PediatricPeripheral vascular diseasePharmacologyShock

Identifiers

PMID38099637
PMCPMC10723573
OpenAlexW4389787554

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.