Evidence map›Paper›PMID 38099529›Full record

ArticleCurrent neurovascular research2025

Albumin-Globulin Ratio and Common Carotid Artery Intima-Media Thickness in Patients with Ischemic Stroke.

Qiao Han, Shoujiang You, Mengyuan Miao, Danni Zheng, Huaping Du, Yaming Sun, Wanqing Zhai, Chongke Zhong, Yongjun Cao, Chun-Feng Liu

Abstract read
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In one paragraph

Article in Current neurovascular research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Qiao HanDepartment of Neurology, Suzhou TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou, 215009, China.
Shoujiang YouDepartment of Neurology and Suzhou Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, China.
Mengyuan MiaoDepartment of Epidemiology, School of Public Health, Medical College of Soochow University, Suzhou, 215123, China.
Danni ZhengFaculty of Medicine, The George Institute for Global Health, University of New South Wales, NSW, Australia.
Huaping DuDepartment of Neurology, Suzhou Ninth People's Hospital, Suzhou, 215000, China.
Yaming SunDepartment of Neurology, Zhangjiagang TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou, 215600, China.
Wanqing ZhaiDepartment of Neurology, The First People's Hospital of Taicang, Suzhou 215400, China.
Chongke ZhongDepartment of Epidemiology, School of Public Health, Medical College of Soochow University, Suzhou, 215123, China.
Yongjun CaoDepartment of Neurology and Suzhou Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, China.
Chun-Feng LiuDepartment of Neurology and Suzhou Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, China.
Soochow University · CNNanjing University of Chinese Medicine · CNTaizhou First People's Hospital · CNThe Fifth People’s Hospital of Suzhou · CNUNSW Sydney · AU

Funding

Discipline Construction Program of the Second Affiliated Hospital of Soochow University XKTJ-XK202001, XKTJ-TD202004Gusu Health Talents Program GSWS2020029Jiangsu Provincial Medical Key Discipline ZDXK202217National Natural Science Foundation of China 81901198, 82171296, 82273706
6 · The paper itself

Abstract

backgroundThe relationships between serum albumin, albumin-globulin (A/G) ratio, globulin and atherosclerosis in acute ischemic stroke (AIS) remain uncertain. We investigated the associations between serum albumin, A/G ratio, globulin levels and carotid atherosclerosis in patients with AIS.

methodsA total of 1,339 AIS patients were enrolled. Admission A/G ratio was divided into quartiles, and serum albumin and globulin levels were also categorized. Carotid atherosclerosis was detected through the assessment of common carotid artery intima-media thickness (cIMT), and abnormal cIMT was characterized by mean and maximum cIMT values of ≥1 mm. We evaluated the relationships between A/G ratio, albumin, globulin and abnormal cIMT, using multivariable logistic regression models.

resultsIn the multivariable-adjusted analysis, the highest A/G ratio quartile (Q4) was linked to a 59% decreased risk of abnormal mean cIMT (OR 0.41; 95% CI 0.29-0.60) and a 58% decreased risk of abnormal maximum cIMT (OR 0.42; 95% CI 0.30-0.60) when compared to the lowest quartile (Q1), respectively. Moreover, decreased albumin and elevated globulin levels were also associated with abnormal mean cIMT and maximum cIMT. In addition, the A/G ratio provided supplementary predictive capability beyond the already established risk factors, and the C-statistic of the A/G ratio for abnormal cIMT is larger than globulin (P <0.01).

conclusionDecreased serum A/G ratio, albumin and elevated serum globulin were independently associated with abnormal cIMT in AIS patients. Moreover, the A/G ratio appeared to be a better predictor of abnormal cIMT.

Indexed as

Carotid Intima-Media ThicknessIschemic StrokeSerum AlbuminSerum GlobulinsAgedAged, 80 and overFemaleHumansMaleMiddle AgedSerum AlbuminSerum GlobulinsAlbumin/globulin ratioatherosclerosiscarotid artery intima-media thicknessCreactive protein.ischemic strokeserum albumin

Identifiers

PMID38099529
OpenAlexW4389795545

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.