Evidence map›Paper›PMID 38099327›Full record

ArticlePlatelets2024

Role of platelet count in a murine stasis model of deep vein thrombosis.

Rick Mathews, Naly Setthavongsack, Anh Le-Cook, Andy Kaempf, Jennifer M Loftis, Randall L Woltjer, Christina U Lorentz, Alexey Revenko, Monica T Hinds, Khanh P Nguyen

Open access · goldAbstract read
In one paragraph

Article in Platelets, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Rick MathewsDepartment of Biomedical Engineering, Oregon Health & Science University, Portland, OR, USA.ORCID 0000-0003-2723-5646
Naly SetthavongsackDivision of Neuropathology, Department of Pathology, Oregon Health and Science University, Portland, OR, USA.ORCID 0000-0002-8358-9062
Anh Le-CookResearch & Development Service, VA Portland Health Care System, Portland, OR, USA.ORCID 0000-0002-8230-2453
Andy KaempfBiostatistics Shared Resource, Knight Cancer Institute, Oregon Health and Science University, Portland, OR, USA.ORCID 0000-0001-9425-6936
Jennifer M LoftisResearch & Development Service, VA Portland Health Care System, Portland, OR, USA.ORCID 0000-0003-1773-9365
Randall L WoltjerDivision of Neuropathology, Department of Pathology, Oregon Health and Science University, Portland, OR, USA.ORCID 0000-0003-0755-9846
Christina U LorentzAronora, Inc, Portland, OR, USA.ORCID 0000-0002-6885-2352
Alexey RevenkoIonis Pharmaceuticals, Inc, Carlsbad, CA, USA.ORCID 0000-0002-4863-362X
Monica T HindsDepartment of Biomedical Engineering, Oregon Health & Science University, Portland, OR, USA.ORCID 0000-0002-5267-3376
Khanh P NguyenDepartment of Biomedical Engineering, Oregon Health & Science University, Portland, OR, USA.ORCID 0000-0003-3605-3406
Oregon Health & Science University · USAronora (United States) · USIonis Pharmaceuticals (United States) · USVA Portland Health Care System · US

Funding

Contact Pathway Activation on Vascular DevicesR01HL144113 · NHLBI · OREGON HEALTH & SCIENCE UNIVERSITY · PI HINDS, MONICA T, MCCARTY, OWEN J · 2018 to 2025
$6.0M
Multidisciplinary Research Training in Pulmonary MedicineT32HL083808 · NHLBI · OREGON HEALTH & SCIENCE UNIVERSITY · PI LEWINSOHN, DAVID M., SLATORE, CHRISTOPHER G. · 2008 to 2025
$5.3M
Biodegradable Metal Stent Alloys for Vascular ApplicationsR01HL168696 · NHLBI · OREGON HEALTH & SCIENCE UNIVERSITY · PI Jeremy Goldman, Monica T Hinds · 2023 to 2026
$2.8M
Thrombopoietin Targeting in Myeloproliferative NeoplasmsR44HL162386 · NHLBI · ARONORA, INC. · PI LORENTZ, CHRISTINA U, TUCKER, ERIK IAN · 2022 to 2024
$1.7M
Medical Scientist Training Program of Oregon Health & Science UniversityT32GM109835 · NIGMS · OREGON HEALTH & SCIENCE UNIVERSITY · PI JACOBY, DAVID B · 2016 to 2020
$1.1M
Role of glycosaminoglycans (GAGs) in deep vein thrombus formation and resolutionF30HL163918 · NHLBI · OREGON HEALTH & SCIENCE UNIVERSITY · PI MATHEWS, RICK · 2022 to 2025
$213k
Mechanisms of Deep Vein Thrombosis (DVT) and Vein Wall FibrosisIK2CX001720 · VA · PORTLAND VA MEDICAL CENTER · PI Khanh P. Nguyen · 2020 to 2026
–
HCV and co-morbid alcohol use disorders: a translational investigation of antiviral therapy outcomes on CNS functionI01BX002061 · VA · PORTLAND VA MEDICAL CENTER · PI LOFTIS, JENNIFER M · 2014 to 2023
–
BLRD VA I01 BX002061CSRD VA I01 CX002668CSRD VA IK2 CX001720NHLBI NIH HHS F30 HL163918NHLBI NIH HHS R01 HL144113NHLBI NIH HHS R01 HL168696NHLBI NIH HHS R44 HL162386NHLBI NIH HHS T32 HL083808NIGMS NIH HHS T32 GM109835
6 · The paper itself

Abstract

Platelets are core components of thrombi but their effect on thrombus burden during deep vein thrombosis (DVT) has not been fully characterized. We examined the role of thrombopoietin-altered platelet count on thrombus burden in a murine stasis model of DVT. To modulate platelet count compared to baseline, CD1 mice were pretreated with thrombopoietin antisense oligonucleotide (THPO-ASO, 56% decrease), thrombopoietin mimetic (TPO-mimetic, 36% increase), or saline (within 1%). Thrombi and vein walls were examined on postoperative days (POD) 3 and 7. Thrombus weights on POD 3 were not different between treatment groups (

Indexed as

ThrombosisVenous ThrombosisAnimalsBlood PlateletsHumansMicePlatelet CountThrombopoietinThrombopoietinDeep vein thrombosisplateletspostthrombotic syndromethrombusveins

Identifiers

PMID38099327
PMCPMC10805383
OpenAlexW4389793050

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.