Evidence map›Paper›PMID 38099197›Full record

ReviewFrontiers in molecular biosciences2023

Regulatory mechanisms triggered by enzyme interactions with lipid membrane surfaces.

Jie Yu, David D Boehr

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in molecular biosciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Jie YuDepartment of Chemistry, The Pennsylvania State University, University Park, PA, United States.
David D BoehrDepartment of Chemistry, The Pennsylvania State University, University Park, PA, United States.
Pennsylvania State University · US

Funding

Watching Conformational Rearrangements in Poliovirus RNA-Dependent RNA PolymeraseR01AI104878 · NIAID · PENNSYLVANIA STATE UNIVERSITY, THE · PI BOEHR, DAVID DOUGLAS · 2014 to 2024
$3.0M
NIAID NIH HHS R01 AI104878
6 · The paper itself

Abstract

Recruitment of enzymes to intracellular membranes often modulates their catalytic activity, which can be important in cell signaling and membrane trafficking. Thus, re-localization is not only important for these enzymes to gain access to their substrates, but membrane interactions often allosterically regulate enzyme function by inducing conformational changes across different time and amplitude scales. Recent structural, biophysical and computational studies have revealed how key enzymes interact with lipid membrane surfaces, and how this membrane binding regulates protein structure and function. This review summarizes the recent progress in understanding regulatory mechanisms involved in enzyme-membrane interactions.

Indexed as

allosteric regulationconformational changelipid kinaselipid metabolismphosphatidylinositol phosphate lipidsprotein-membrane interactionssignaling

Identifiers

PMID38099197
PMCPMC10720463
OpenAlexW4389200348

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.