Evidence map›Paper›PMID 38099057›Full record

ArticleRSC medicinal chemistry2023

Discovery of pyrazolopyrimidines that selectively inhibit CSF-1R kinase by iterative design, synthesis and screening against glioblastoma cells.

Daniel J Baillache, Teresa Valero, Álvaro Lorente-Macías, David Jonathan Bennett, Richard J R Elliott, Neil O Carragher, Asier Unciti-Broceta

Open access · hybridAbstract read
In one paragraph

Article in RSC medicinal chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 3 countries.

Daniel J BaillacheEdinburgh Cancer Research, Institute of Genetics & Cancer, University of Edinburgh Crewe Road South Edinburgh EH4 2XR UK asier.ub@ed.ac.uk.ORCID https://orcid.org/0000-0003-0859-829X
Teresa ValeroEdinburgh Cancer Research, Institute of Genetics & Cancer, University of Edinburgh Crewe Road South Edinburgh EH4 2XR UK asier.ub@ed.ac.uk.ORCID https://orcid.org/0000-0002-3625-311X
Álvaro Lorente-MacíasEdinburgh Cancer Research, Institute of Genetics & Cancer, University of Edinburgh Crewe Road South Edinburgh EH4 2XR UK asier.ub@ed.ac.uk.ORCID https://orcid.org/0000-0001-9510-714X
David Jonathan BennettMerck & Co., Inc. Boston Massachusetts 02115 USA.
Richard J R ElliottEdinburgh Cancer Research, Institute of Genetics & Cancer, University of Edinburgh Crewe Road South Edinburgh EH4 2XR UK asier.ub@ed.ac.uk.
Neil O CarragherEdinburgh Cancer Research, Institute of Genetics & Cancer, University of Edinburgh Crewe Road South Edinburgh EH4 2XR UK asier.ub@ed.ac.uk.ORCID https://orcid.org/0000-0001-5541-9747
Asier Unciti-BrocetaEdinburgh Cancer Research, Institute of Genetics & Cancer, University of Edinburgh Crewe Road South Edinburgh EH4 2XR UK asier.ub@ed.ac.uk.ORCID https://orcid.org/0000-0003-1029-2855
Universidad de Granada · ESMerck & Co., Inc., Rahway, NJ, USA (United States) · US

Funding

Cancer Research UK 28596
6 · The paper itself

Abstract

Glioblastoma multiforme (GBM) is the most aggressive type of brain cancer in adults, with an average life expectancy under treatment of approx. 15 months. GBM is characterised by a complex set of genetic alterations that results in significant disruption of receptor tyrosine kinase (RTK) signaling. We report here an exploration of the pyrazolo[3,4-

Identifiers

PMID38099057
PMCPMC10718585
OpenAlexW4387545012

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.