Observational studyFrontiers in endocrinology2023
Association between serum uric acid level and bone mineral density in men more than 50 years of age.
Observational study in Frontiers in endocrinology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- An intelligent auxiliary diagnostic system for early osteoporosis screening using stacking ensemble learning.BMC medical informatics and decision making · 2026Article
- Association between serum uric acid levels and lumbar spine Z-scores in adults aged <50 years: A cross-sectional study.Metabolism open · 2026Article
- Sex-Specific Biological Predictors for Identifying Individuals With Low Bone Mineral Density Using the Taiwan Biobank Database.Journal of osteoporosis · 2026Article
- Association between the serum uric acid to HDL cholesterol ratio and forearm bone mineral density in middle-aged and older adults.Frontiers in endocrinology · 2026Article
- Influence of serum uric acid on bone mineral density across body mass index categories in men with type 2 diabetes: a cross-sectional study.BMC musculoskeletal disorders · 2025Article
- Construction and validation of a nomogram for screening for sarcopenia in patients with osteoporotic vertebral compression fracture.Scientific reports · 2025Article
- Association of visceral fat metabolic score with bone mineral density and osteoporosis: a NHANES cross-sectional study.Journal of health, population, and nutrition · 2025Article
- Bicarbonate-Rich Mineral Water Mitigates Hypoxia-Induced Osteoporosis in Mice via Gut Microbiota and Metabolic Pathway Regulation.Nutrients · 2025Article
- Association between serum uric acid levels and bone mineral density in Chinese and American: a cross-sectional study.Scientific reports · 2025Article
- Development of a machine learning-based predictive model for osteoporosis risk and its application in clinical decision support.Frontiers in medicine · 2025Article
- A body composition-based clustering study and its association with metabolic phenotypes among the general population in China.Frontiers in nutrition · 2025Article
- Nonlinear Association Between Serum Uric Acid and Femoral Neck Bone Mineral Density in Male Patients with Metabolic Dysfunction-Associated Fatty Liver Disease.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025Article
- The impact of uric acid on musculoskeletal diseases: clinical associations and underlying mechanisms.Frontiers in endocrinology · 2025Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The results of previous studies on the association between serum uric acid levels and bone mineral density and the risk of osteoporosis are controversial. Fat free mass (FFM) is more strongly associated with bone mineral density (BMD) than it is with body fat mass (BFM). Skeletal muscle mass is assumed to contribute indirectly to the relationship between serum uric acid levels and BMD. Therefore, we aimed to evaluate the association between serum uric acid levels and BMD and abnormal BMD (at least osteopenia) by considering body composition in men aged ≥ 50 years. Methods: This was a retrospective observational cross-sectional study. We used data obtained from 2,991 men aged ≥50 years who completed questionnaires, anthropometric surveys, laboratory tests, and bone mineral density scans. A subgroup analysis of 1,135 men who additionally underwent body composition data analysis using Inbody Results: Positive correlations between serum uric acid levels and BMD at the three sites (L1-L4, Femur neck, Femur total) were observed in unadjusted and fully adjusted models except the BMD of the femoral neck (P-value=0.054).Furthermore, FFM and skeletal muscle mass index (SMI) showed positive association with serum uric acid level and BMD at three sites, with statistical significance. An increase in serum uric acid level was associated with a lower risk of abnormal BMD after adjusting for confounders including FFM and SMI. Conclusion: Serum uric acid level was positively associated with BMD at three sites and had a protective effect against abnormal BMD after adjusting for multiple confounders, including FFM and SMI, in men aged ≥ 50 years.
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