Evidence map›Paper›PMID 38098703›Full record

ArticleChemical science2023

Improving the potential of paraCEST through magnetic-coupling induced line sharpening.

Xin Guo, Lei Zhang, Jiesheng Hu, Balázs Szilágyi, Meng Yu, Shizhen Chen, Gyula Tircsó, Xin Zhou, Jun Tao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xin GuoKey Laboratory of Cluster Science of Ministry of Education, School of Chemistry and Chemical Engineering, Liangxiang Campus, Beijing Institute of Technology Beijing 102488 China mengyu@bit.edu.cn taojun@bit.edu.cn.
Lei ZhangState Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, National Center for Magnetic Resonance in Wuhan, Wuhan Institute of Physics and Mathematics, Innovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences, Wuhan National Laboratory for Optoelectronics Wuhan 430071 China chenshizhen@wipm.ac.cn.
Jiesheng HuKey Laboratory of Cluster Science of Ministry of Education, School of Chemistry and Chemical Engineering, Liangxiang Campus, Beijing Institute of Technology Beijing 102488 China mengyu@bit.edu.cn taojun@bit.edu.cn.
Balázs SzilágyiDepartment of Physical Chemistry, Faculty of Science and Technology, University of Debrecen Egyetem tér 1 H-4032 Debrecen Hungary.
Meng YuKey Laboratory of Cluster Science of Ministry of Education, School of Chemistry and Chemical Engineering, Liangxiang Campus, Beijing Institute of Technology Beijing 102488 China mengyu@bit.edu.cn taojun@bit.edu.cn.ORCID https://orcid.org/0000-0001-7570-5695
Shizhen ChenState Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, National Center for Magnetic Resonance in Wuhan, Wuhan Institute of Physics and Mathematics, Innovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences, Wuhan National Laboratory for Optoelectronics Wuhan 430071 China chenshizhen@wipm.ac.cn.
Gyula TircsóDepartment of Physical Chemistry, Faculty of Science and Technology, University of Debrecen Egyetem tér 1 H-4032 Debrecen Hungary.ORCID https://orcid.org/0000-0002-7896-7890
Xin ZhouState Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, National Center for Magnetic Resonance in Wuhan, Wuhan Institute of Physics and Mathematics, Innovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences, Wuhan National Laboratory for Optoelectronics Wuhan 430071 China chenshizhen@wipm.ac.cn.ORCID https://orcid.org/0000-0002-5580-7907
Jun TaoKey Laboratory of Cluster Science of Ministry of Education, School of Chemistry and Chemical Engineering, Liangxiang Campus, Beijing Institute of Technology Beijing 102488 China mengyu@bit.edu.cn taojun@bit.edu.cn.ORCID https://orcid.org/0000-0003-0610-4305

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Magnetic coupling between paramagnetic centers is a crucial phenomenon in the design of efficient MRI contrast agents. In this study, we investigate the paraCEST properties and magnetic coupling effects of a novel homodinuclear Ni(ii) complex, 1, containing a Robson type macrocyclic ligand. A thorough analysis of the complex's electronic and magnetic properties revealed that the magnetic coupling effect reduces the transverse relaxation rate and enhances the sharpness of the proton resonances, leading to enhanced CEST efficiency. This novel mechanism, which we coined "magnetic-coupling induced line sharpening" (MILS), can be crucial for optimizing the performance of paramagnetic metal complexes in paraCEST imaging. Moreover, magnetic coupling plays a critical role in the relaxation properties of homodinuclear complexes. Our study not only paves the way for the creation of advanced paraCEST agents with enhanced CEST capabilities and sensitivity but also provides valuable guidance for the design of other MRI contrast agents utilizing dinuclear metal complexes.

Identifiers

PMID38098703
PMCPMC10717539

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