Evidence map›Paper›PMID 38098555›Full record

ReviewAnnals of medicine and surgery (2012)2023

Serum trimethylamine N-oxide levels among coronary artery disease and acute coronary syndrome patients: a systematic review and meta-analysis.

Yomna E Dean, Samah S Rouzan, Jose J Loayza Pintado, Nesreen Elsayed Talat, Alaa R H Mohamed, Suman Verma, Zainab Anwar Kamdi, Deepak Gir, Ahmed Helmy, Zakaria Helmy and 4 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Annals of medicine and surgery (2012), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Yomna E DeanAlexandria University, Faculty of Medicine, Alexandria.
Samah S RouzanAlexandria University, Faculty of Medicine, Alexandria.
Jose J Loayza PintadoUniversidad de San Martin de Porres Facultad de Medicina Humana, Peru.
Nesreen Elsayed TalatAlexandria University, Faculty of Medicine, Alexandria.
Alaa R H MohamedSuez Canal University, Faculty of Medicine, Ismailia.
Suman VermaMaharishi Markandeshwar Medical College and Hospital, Solan, India.
Zainab Anwar KamdiDow University of Health Sciences, Karachi, Pakistan.
Deepak GirSt. Joseph's Medical Center, Stockton, CA, USA.
Ahmed HelmyKharkiv National Medical University, Kharkiv, Ukraine.
Zakaria Helmy6th October University, Faculty of Medicine, Giza, Egypt.
Ahson AfzalDow University of Health Sciences, Karachi, Pakistan.
Tamer MadyInternational American University, College of Medicine, Saint Lucia, Caribbean.
Yusef HazimehLebanese University.
Hani Aiash6th October University, Faculty of Medicine, Giza, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and Aim: Recent studies have linked trimethylamine N-oxide (TMAO) to cardiovascular diseases; our study aimed to analyze the association between coronary artery disease (CAD), acute coronary syndrome (ACS), and TMAO. Methods: PubMed, Scopus, Embase, and Web of Science were searched using terms such as 'CAD' and 'TMAO'. Only observational controlled studies were included. RevMan software version 5.4 was used for the analysis. Results: A significant association was found between the CAD group and increased serum TMAO levels compared with the control group (MD=1.16, 95% CI=0.54-1.78, Conclusion: TMAO is an acceptable diagnostic marker for CAD, with significantly higher levels among these patients regardless of their age. Other metabolites did not show such an association. The role of serum level TMAO in the early diagnosis of CAD should be further explored.

Indexed as

coronary artery diseasegastrointestinal microbiomemicrobiotaTMAO

Identifiers

PMID38098555
PMCPMC10718322

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.