Evidence map›Paper›PMID 38098149›Full record

ArticleMedicine and science in sports and exercise2024

Physical Activity and High-Sensitivity C-Reactive Protein in Pregnancy: Does It Matter during Leisure or Work?

Xinyue Liu, Liwei Chen, Jian Li, Andreas Holtermann, Ruijin Lu, Anna Birukov, Natalie L Weir, Michael Y Tsai, Cuilin Zhang

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Medicine and science in sports and exercise, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 3 countries.

Xinyue LiuDepartment of Epidemiology, Fielding School of Public Health, University of California Los Angeles, Los Angeles, CA.
Liwei ChenDepartment of Epidemiology, Fielding School of Public Health, University of California Los Angeles, Los Angeles, CA.
Jian Li
Andreas HoltermannNational Research Centre for the Working Environment, Copenhagen, DENMARK.
Ruijin LuSchool of Medicine, Washington University in St. Louis, St. Louis, MO.
Anna BirukovDepartment of Nutrition, T.H. Chan School of Public Health, Harvard University, Boston, MA.
Natalie L WeirDepartment of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN.
Michael Y TsaiDepartment of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN.
Cuilin Zhang
University of California, Los Angeles · USHarvard University · USUniversity of Minnesota · USNational Research Centre for the Working Environment · DKWashington University in St. Louis · US

Funding

Southern California Education and Research Center T42OH008412 · OH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI JONES, RACHAEL MARY · 2005 to 2025
$28.1M
Reducing disparities in birth outcomes: a randomized controlled trial on CenteringPregnancyR01HD082311 · NICHD · CLEMSON UNIVERSITY · PI CROCKETT, AMY HAIRSTON, HEO, MOONSEONG · 2015 to 2019
$2.7M
NICHD NIH HHS R01 HD082311NIOSH CDC HHS T42 OH008412
6 · The paper itself

Abstract

introductionPhysical activity (PA), regardless of domain, is recommended for pregnant individuals in clinical guidelines, but limited evidence is available for work-related PA. This study aimed to examine the associations of occupational (OPA) and leisure-time PA (LTPA) with plasma high-sensitivity C-reactive protein (hs-CRP), a risk marker for adverse pregnancy outcomes, among pregnant individuals.

methodsThis longitudinal study included 257 workers in the fetal growth cohort. OPA/LTPA and hs-CRP were measured in each trimester. OPA/LTPA was divided into high and low groups by the median level. Multivariable linear regressions were applied to estimate the adjusted geometric mean differences of hs-CRP (mg·L-1) comparing high versus low OPA/LTPA in each trimester and the changes in OPA/LTPA over pregnancy.

resultsOPA was positively associated with hs-CRP (high: 5.14 vs low: 3.59; P value: 0.001) in the first trimester, particularly for standing/walking or walking fast, regardless of carrying things. LTPA was negatively associated with hs-CRP in the second (high: 3.93 vs low: 5.08; 0.02) and third trimesters (high: 3.30 vs low: 4.40; 0.046). Compared with the low OPA + high LTPA group, hs-CRP was higher in both the high OPA + high LTPA and high OPA + low LTPA groups in the first trimester, and in the high OPA + low LTPA group only in the third trimester. The change in OPA during pregnancy was positively associated with hs-CRP, whereas the change in LTPA was negatively associated with hs-CRP from the second to the third trimester.

conclusionsIn pregnant individuals, LTPA was negatively associated with hs-CRP, whereas OPA was positively associated with hs-CRP. More research on OPA's health impact among pregnant individuals is needed, and guidelines may consider the potential unfavorable influence of OPA on pregnant individuals.

Indexed as

C-Reactive ProteinExerciseFemaleHumansLeisure ActivitiesLongitudinal StudiesPregnancyWalkingC-Reactive Protein

Identifiers

PMID38098149
PMCPMC12995286
OpenAlexW4389799697

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.