ArticleWorld journal of surgical oncology2023
Serum concentrations of proinflammatory biomarker interleukin-6 (IL-6) as a predictor of postoperative complications after elective colorectal surgery.
Article in World journal of surgical oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.
- IL-6 and Surgical Outcomes in Carotid Endarterectomy: A Systematic Review.Medical sciences (Basel, Switzerland) · 2025Pooled it
- Low preoperative adiponectin levels are associated with postoperative systemic inflammatory response following major colorectal cancer surgery.Intensive care medicine experimental · 2026Article
- Mechanisms of vaginal bacteria-induced fetal membrane damage and tocilizumab's therapeutic potential in PPROM.BMC pregnancy and childbirth · 2026Article
- Multimodal prehabilitation and perioperative immune function in patients undergoing abdominal cancer surgery.The British journal of surgery · 2026Article
- Cytokines at the Crossroads of Mitochondrial Dysfunction and Inflammation in Colorectal Cancer: Implications for Postoperative Complications.Molecular diagnosis & therapy · 2026Review
- Analysis of the predictive value of age and serum IL-6 level at 24-hour postoperatively for prolonged postoperative ileus after laparoscopic colorectal cancer surgery.World journal of surgical oncology · 2026Article
- Postoperative Complications in Patients with Frailty Syndrome Undergoing Esophagectomy-A Systematic Review with Meta-Analysis.Journal of clinical medicine · 2026Review
- Fascia iliaca compartment block for surgical analgesia in children with osteogenesis imperfecta: A retrospective cohort study.PloS one · 2026Article
- Lambda Theta Reflectometry: A New Technique for Measuring Optical Film Thickness in Planar Protein Arrays.ACS sensors · 2025Article
- Observational
- Preoperative TNF-α predicts uneventful postoperative outcomes in patients undergoing colorectal cancer surgery.Scientific reports · 2025Observational
- Inconsistent Associations of Modified Frailty Index-5 With Adverse Head and Neck Reconstruction Outcomes.The Laryngoscope · 2025Article
- Integrating serological and drainage fluid indicators: developing two predictive models for early detection of postoperative intra-abdominal infections in gastrointestinal tumor patients.Frontiers in oncology · 2025Article
- Efficiency of IL-6 in Early Prognosis and Follow-Up in Critically Ill Patients with Septic Shock.Diseases (Basel, Switzerland) · 2024Article
- Effects of intravenous inflammasome inhibitor (NuSepin) on suppression of proinflammatory cytokines release induced by cardiopulmonary bypass in swine model: a pilot study.Scientific reports · 2024Article
- Machine learning identifies a 5-serum cytokine panel for the early detection of chronic atrophy gastritis patients.Cancer biomarkers : section A of Disease markers · 2024Article
- Abdominal wound length influences the postoperative serum level of interleukin-6 and recovery of flatus passage among patients with colorectal cancer.Frontiers in surgery · 2024Article
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Authors and funding
9 authors at 3 institutions in 1 country.
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Abstract
backgroundThe aim of this prospective study was to evaluate the role of serum IL-6 as a potential predictive biomarker of postoperative complications (POC) in elective colorectal surgery.
methodA total of 115 patients underwent colorectal surgery for malignancy. IL-6 was measured on the first and third postoperative days (POD1, POD3), and C-reactive protein (CRP) was measured on the POD3. POC was analysed in subgroups according to Clavien‒Dindo (CD), antibiotic (ATB) treatment, intensive care unit (ICU) and hospital length of stay. The predictive power of variables for evaluated endpoints was analysed using receiver-operating characteristic (ROC) analysis and described by area under the curve (AUC). ROC analysis was adopted for the identification of optimal cut-offs. Histological analysis was performed to verify IL-6 production by the tumour.
resultsOut of 115 patients who were analysed, 42% had POC. Patients with POC had significantly higher serum levels of IL-6 on POD1 (p < 0.001) and POD3 (p < 0.001). IL-6 early on POD1 as a predictor of antibiotic treatment, ICU stay and hospital stay (AUC 0.818; 0.811; 0.771) did not significantly differ from the AUC of CRP late on POD3 (0.879; 0.838, 0.752). A cut-off IL-6 value of 113 pg/ml on POD1 and 180.5 pg/ml on POD3 in severe complications (CD > 3a) resulted in 75% and 72% sensitivity, 78.6% and 99% specificity, negative predictive value 96.4% and 97% and positive predictive value 29% and 88.9%.
conclusionThe serum level of interleukin-6 can predict severe (CD > 3a) POC early on POD1. On POD3, IL-6 is superior to CRP in terms of high positive predictive power of severe POC. Interestingly, the advantage of IL-6 on POD1 is early prediction of the need for antibiotic treatment, ICU stay and hospital stay, which is comparable to the CRP serum level late on the third POD.
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