ReviewWorld journal of surgical oncology2023
Lymphovascular invasion is a significant risk factor for non-sentinel nodal metastasis in breast cancer patients with sentinel lymph node (SLN)-positive breast cancer: a cross-sectional study.
Review in World journal of surgical oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 8 citations in OpenAlex.
- Intratumoral and peritumoral-based radiomics for assessment of lymphovascular invasion in invasive breast cancer: model development and validation.Translational cancer research · 2026Article
- Metastatic presentation of breast cancer in India: evidence from national cancer registry (2009-2020).The Lancet regional health. Southeast Asia · 2026Article
- The Value of the Preoperative Hematological Inflammatory Markers for Predicting Lymphovascular Invasion in Gastric Cancer.ImmunoTargets and therapy · 2026Article
- Risk factors for anastomotic leakage in rectal cancer surgery reflecting current practices.Surgery today · 2025Article
- Hormone Receptor-Dependent Correlations Between Angiopoietins and VEGF-C in Primary Breast Cancer: Insights Into Lymphangiogenic Biomarkers.Cancer reports (Hoboken, N.J.) · 2025Article
- Prognostic Insights in Feline Mammary Carcinomas: Clinicopathological Factors and the Proposal of a New Staging System.Animals : an open access journal from MDPI · 2025Article
- Clinical impact of the Z0011 trial on axillary surgical management in Australia and New Zealand from the BreastSurgANZ Quality Audit.ANZ journal of surgery · 2025Article
- Article
- The Impact of Lymphoscintigraphy Visualization on the Prognosis of Early Breast Cancer Patients Undergoing Sentinel Node Biopsy: A 20-year, Single-center Experience.Cancer diagnosis & prognosisArticle
- Transformer-Based Deep Learning Model Using MRI-Derived Microvascular Atlas for Predicting Lymphovascular Invasion in Breast Cancer Patients.Technology in cancer research & treatmentArticle
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundA connection between lymphovascular invasion and axillary lymph node metastases in breast cancer has been observed, but the findings are inconsistent and primarily based on research in Western populations. We investigated the association between lymphovascular invasion and non-sentinel lymph node (non-SLN) metastasis in breast cancer patients with sentinel lymph node (SLN) metastasis in western China.
methodsThis study comprised 280 breast cancer patients who tested positive for SLN through biopsy and subsequently underwent axillary lymph node dissection (ALND) at The People's Hospital of Guangxi Zhuang Autonomous Region between March 2013 and July 2022. We used multivariate logistic regression analyses to assess the association between clinicopathological characteristics and non-SLN metastasis. Additionally, we conducted further stratified analysis.
resultsAmong the 280 patients with positive SLN, only 126 (45%) exhibited non-SLN metastasis. Multivariate logistic regression demonstrated that lymphovascular invasion was an independent risk factor for non-SLN in breast cancer patients with SLN metastasis (OR = 6.11; 95% CI, 3.62-10.32, p < 0.05). The stratified analysis yielded similar results.
conclusionsIn individuals with invasive breast cancer and 1-2 positive sentinel lymph nodes, lymphovascular invasion is the sole risk factor for non-SLN metastases. This finding aids surgeons and oncologists in devising a plan for local axillary treatment, preventing both over- and undertreatment.
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