Evidence map›Paper›PMID 38097848›Full record

ArticleJournal of endocrinological investigation2024

Correlation study between bone metabolic markers, bone mineral density, and sarcopenia.

W Q Xie, M He, D J Yu, H Z Li, H F Jin, B Z Ji, G Yang, L L Chen, M Rahmati, Y S Li

Erratum issuedAbstract read
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In one paragraph

Article in Journal of endocrinological investigation, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

W Q XieDeparment of Orthopedics, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China.ORCID http://orcid.org/0000-0001-9810-7372
M HeDeparment of Orthopedics, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China.
D J YuDeparment of Orthopedics, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China.
H Z LiDeparment of Orthopedics, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China.
H F JinDeparment of Orthopedics, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China.
B Z JiDeparment of Orthopedics, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China.
G YangDeparment of Orthopedics, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China.
L L ChenHunan Key Laboratory for Bioanalysis of Complex Matrix Samples, Changsha, 410000, Hunan, China.
M RahmatiDepartment of Physical Education and Sport Sciences, Faculty of Literature and Human Sciences, Lorestan University, Khorramabad, Iran.
Y S LiDeparment of Orthopedics, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China. liyusheng@csu.edu.cn.
Central South University · CNVali Asr University of Rafsanjan · IR

Funding

National Natural Science Foundation of China 82072506National Natural Science Foundation of China 92268115
6 · The paper itself

Abstract

objectiveTo investigate the correlation between bone metabolism markers, bone mineral density (BMD), and sarcopenia.

methodsA total of 331 consecutive patients aged ≥ 60 years who were hospitalized between November 2020 and December 2021 were enrolled. Participants were divided into sarcopenia and non-sarcopenia groups according to the Asian Working Group on Sarcopenia criteria (AWGS, 2019). The clinical data, bone metabolism markers (β-CTX, N-MID, and TP1NP), and BMD were compared between the two groups.

resultsAge, β-CTX, and N-MID of the sarcopenia group were higher than those of the non-sarcopenia group (P < 0.05), but the BMD T values were lower than those of the non-sarcopenia group (P < 0.05). Binary logistic regression analysis showed that increased femoral neck BMD (FNBMD) was a protective factor for sarcopenia, while increased β-CTX was a risk factor. Pearson/Spearman correlation analysis showed that the diagnostic indices of sarcopenia were positively correlated with FNBMD and negatively correlated with β-CTX and N-MID. Multiple linear regression analysis revealed that BMI and FNBMD significantly positively affected muscle strength and appendicular skeletal muscle mass (ASM). The FNBMD significantly positively affected physical performance, while β-CTX significantly negatively affected muscle strength, ASM, and physical performance.

conclusionIncreased FNBMD may be a protective factor against sarcopenia, and increased β-CTX may be a risk factor. The FNBMD significantly positively affected the diagnostic indices of sarcopenia, while β-CTX significantly negatively affected them. BMD and bone metabolism marker levels may be considered in early screening for sarcopenia.

Indexed as

BiomarkersBone DensitySarcopeniaAgedBone and BonesCollagen Type IFemaleHumansMaleMiddle AgedMuscle, SkeletalMuscle StrengthPeptide FragmentsProcollagenBiomarkersCollagen Type IPeptide FragmentsProcollagenBone metabolism markerBone mineral densityMuscle massMuscle strengthPhysical performanceSarcopenia

Identifiers

PMID38097848
OpenAlexW4389722612

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.