ArticleNature biomedical engineering2024
Restoration of sensory feedback from the foot and reduction of phantom limb pain via closed-loop spinal cord stimulation.
Article in Nature biomedical engineering, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 32 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.
- Spinal Cord Stimulation for Painful Diabetic Neuropathy: A Systematic Review and Meta-Analysis of High- and Low-Frequency Modalities.Pain research & management · 2026Pooled it
- Functional Somatotopy of Lumbar Dorsal Rootlets and its Role in Selective Recruitment via Lateral Spinal Cord Stimulation.bioRxiv : the preprint server for biology · 2026Article
- Neuromodulation strategies in postburn care for pain rehabilitation and scar remodelling.Communications medicine · 2026Review
- Perilesional neuromodulation replaces lost sensorimotor function in persons with spinal cord injury.Nature biomedical engineering · 2026Article
- Magnetically Responsive Piezoelectric Nanocapacitors Enhance Neural Recovery Following Spinal Cord Injury via Targeted Spinal Magnetic Stimulation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Long-term outcomes of spinal cord stimulation for refractory phantom limb pain.Frontiers in pain research (Lausanne, Switzerland) · 2026Article
- A Bioinspired Perceptual Sensor for Spatiotemporal Decoding of Haptic and Pain Stimuli in Prostheses.Cyborg and bionic systems (Washington, D.C.) · 2026Article
- Using EMG Biofeedback to Restore Closed-Loop Neural Control on a Powered Prosthetic Ankle.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2026Article
- Enhanced sensory perception and myoelectric control with high channel count implanted sensorimotor systems.Journal of neural engineering · 2025Article
- SpIC3D imaging for spinal in situ contrast 3D visualization.Cell reports methods · 2025Article
- Multidimensional advances in neural interface technology for peripheral nerve repair: From material innovation to clinical translation.Materials today. Bio · 2025Review
- Characterizing spinal reflexes evoked by sensory spinal cord stimulation in people with lower-limb amputation.Journal of neuroengineering and rehabilitation · 2025Article
- Flexible 3D Kirigami Probes for In Vitro and In Vivo Neural Applications.Advanced materials (Deerfield Beach, Fla.) · 2025Article
- An active electronic, high-density epidural paddle array for chronic spinal cord neuromodulation.Journal of neural engineering · 2025Article
- Overcoming failure: improving acceptance and success of implanted neural interfaces.Bioelectronic medicine · 2025Review
- xDev: a mixed-signal, software-defined neurotechnology interface platform for accelerated system development.Journal of neural engineering · 2025Article
- A sensory neuroprosthesis enhances recovery from treadmill-induced stumbles for individuals with lower limb loss.Scientific reports · 2025Article
- Techniques to mitigate lead migration for percutaneous trials of cervical spinal cord stimulation.Frontiers in surgery · 2025Article
- Participant Perspectives on an Invasive Spinal Neuromodulation Study for Functional Sensorimotor and Autonomic Restoration in Chronic Thoracic Spinal Cord Injury: A Qualitative Case Series.Topics in spinal cord injury rehabilitation · 2025Article
- Somatosensory restoration and neural control strategies in lower-limb prostheses.npj biomedical innovations · 2025Review
Corrections and comments
- Erratum issued
Authors and funding
17 authors at 3 institutions in 2 countries.
Funding
Abstract
Restoring somatosensory feedback in individuals with lower-limb amputations would reduce the risk of falls and alleviate phantom limb pain. Here we show, in three individuals with transtibial amputation (one traumatic and two owing to diabetic peripheral neuropathy), that sensations from the missing foot, with control over their location and intensity, can be evoked via lateral lumbosacral spinal cord stimulation with commercially available electrodes and by modulating the intensity of stimulation in real time on the basis of signals from a wireless pressure-sensitive shoe insole. The restored somatosensation via closed-loop stimulation improved balance control (with a 19-point improvement in the composite score of the Sensory Organization Test in one individual) and gait stability (with a 5-point improvement in the Functional Gait Assessment in one individual). And over the implantation period of the stimulation leads, the three individuals experienced a clinically meaningful decrease in phantom limb pain (with an average reduction of nearly 70% on a visual analogue scale). Our findings support the further clinical assessment of lower-limb neuroprostheses providing somatosensory feedback.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.