Evidence map›Paper›PMID 38097780›Full record

ArticleJournal of gastroenterology2024

Thiopurines exert harmful effects on spermatogenesis in Nudt15

Yoshihiro Yokota, Takayuki Imai, Masahiro Kawahara, Osamu Inatomi, Atsushi Nishida, Yoichi Kakuta, Atsushi Masamune, Akira Andoh

Abstract read
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In one paragraph

Article in Journal of gastroenterology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. A Thiopurine-like Mutagenic Process Defines TGCT Subtypes.bioRxiv : the preprint server for biology · 2025
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yoshihiro YokotaDepartment of Medicine, Shiga University of Medical Science, Seta-Tsukinowa, Otsu, Shiga, 520-2192, Japan.
Takayuki ImaiDepartment of Medicine, Shiga University of Medical Science, Seta-Tsukinowa, Otsu, Shiga, 520-2192, Japan.
Masahiro KawaharaDepartment of Medicine, Shiga University of Medical Science, Seta-Tsukinowa, Otsu, Shiga, 520-2192, Japan.
Osamu InatomiDepartment of Medicine, Shiga University of Medical Science, Seta-Tsukinowa, Otsu, Shiga, 520-2192, Japan.
Atsushi NishidaDepartment of Medicine, Shiga University of Medical Science, Seta-Tsukinowa, Otsu, Shiga, 520-2192, Japan.
Yoichi KakutaDivision of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, 980-8575, Japan.
Atsushi MasamuneDivision of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, 980-8575, Japan.
Akira AndohDepartment of Medicine, Shiga University of Medical Science, Seta-Tsukinowa, Otsu, Shiga, 520-2192, Japan. andoh@belle.shiga-med.ac.jp.ORCID 0000-0001-8533-2669

Funding

Japan Society for the Promotion of Science 22K08054the Japan Agency for Medical Research and Development (AMED) JP23ek0410091the Japan Sciences Research Grant for Research on Intractable Diseases (Japanese Inflammatory Bowel Disease Research Group) affiliated with the Japan Ministry of Health, Labour and Welfare 20FC1027
6 · The paper itself

Abstract

backgroundThe association between thiopurine use and testicular reproductive functions remains unclear. In this study, we investigated whether thiopurines affect testicular functions based on the NUDT15 genotypes using Nudt15

methodsThe male Nudt15

resultsAfter MP treatment for 4 weeks, Nudt15

conclusionsThiopurines exert harmful effects on testicular reproductive function according to host NUDT15 genotypes.

Indexed as

PurinesPyrophosphatasesSemenSulfhydryl CompoundsAnimalsMaleMercaptopurineMiceSpermatogenesis2-mercaptopurineMercaptopurinePurinesPyrophosphatasesSulfhydryl CompoundsInflammatory bowel diseaseMercaptopurineNUDT15Spermatogenesis

Identifiers

PMID38097780

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.