Evidence map›Paper›PMID 38097657›Full record

ArticleScientific reports2023

Circulating cytotoxic immune cell composition, activation status and toxins expression associate with white matter microstructure in bipolar disorder.

Veronica Aggio, Lorena Fabbella, Sara Poletti, Cristina Lorenzi, Annamaria Finardi, Cristina Colombo, Raffaella Zanardi, Roberto Furlan, Francesco Benedetti

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Review
  5. Article
  6. Higher Seasonal Variation of Systemic Inflammation in Bipolar Disorder.International journal of molecular sciences · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Veronica AggioPsychiatry and Clinical Psychobiology Unit, Division of Neurosciences, IRCCS San Raffaele Scientific Institute, San Raffaele Turro, Via Stamira d'Ancona 20, 20127, Milano, Italy. aggio.veronica@hsr.it.
Lorena FabbellaClinical Neuroimmunology Unit, Division of Neuroscience, Institute of Experimental Neurology, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Sara PolettiPsychiatry and Clinical Psychobiology Unit, Division of Neurosciences, IRCCS San Raffaele Scientific Institute, San Raffaele Turro, Via Stamira d'Ancona 20, 20127, Milano, Italy.
Cristina LorenziPsychiatry and Clinical Psychobiology Unit, Division of Neurosciences, IRCCS San Raffaele Scientific Institute, San Raffaele Turro, Via Stamira d'Ancona 20, 20127, Milano, Italy.
Annamaria FinardiClinical Neuroimmunology Unit, Division of Neuroscience, Institute of Experimental Neurology, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Cristina ColomboVita-Salute San Raffaele University, Milan, Italy.
Raffaella ZanardiMood Disorders Unit, IRCCS Scientific Institute Ospedale San Raffaele, Milano, Italy.
Roberto FurlanVita-Salute San Raffaele University, Milan, Italy.
Francesco BenedettiPsychiatry and Clinical Psychobiology Unit, Division of Neurosciences, IRCCS San Raffaele Scientific Institute, San Raffaele Turro, Via Stamira d'Ancona 20, 20127, Milano, Italy.
Istituti di Ricovero e Cura a Carattere Scientifico · ITVita-Salute San Raffaele University · ITIRCCS Ospedale San Raffaele · ITIstituto di Ricovero e Cura a Carattere Scientifico San RaffaeleNeuroscience Institute · IT

Funding

European Union H2020 Grant 754740
6 · The paper itself

Abstract

Patients with bipolar disorder (BD) show higher immuno-inflammatory setpoints, with in vivo alterations in white matter (WM) microstructure and post-mortem infiltration of T cells in the brain. Cytotoxic CD8

Indexed as

Bipolar DisorderWhite MatterAnisotropyCD8-Positive T-LymphocytesDiffusion Tensor ImagingGranzymesHumansPerforinGranzymesPerforin

Identifiers

PMID38097657
PMCPMC10721611
OpenAlexW4389742383

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.