Evidence map›Paper›PMID 38097584›Full record

ArticleNature communications2023

The bacterial replication origin BUS promotes nucleobase capture.

Simone Pelliciari, Salomé Bodet-Lefèvre, Stepan Fenyk, Daniel Stevens, Charles Winterhalter, Frederic D Schramm, Sara Pintar, Daniel R Burnham, George Merces, Tomas T Richardson and 5 more

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.9field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. How bacteria initiate DNA replication comes into focus.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025
    Review
  5. Article
  6. mSystems · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 1 country.

Simone PelliciariCentre for Bacterial Cell Biology, Biosciences Institute, Newcastle University, Newcastle Upon Tyne, NE2 4AX, UK.
Salomé Bodet-LefèvreCentre for Molecular Cell Biology, School of Biological and Behavioural Sciences, Queen Mary University of London, Newark Street, London, E1 2AT, UK.ORCID 0000-0001-5135-1626
Stepan FenykCentre for Bacterial Cell Biology, Biosciences Institute, Newcastle University, Newcastle Upon Tyne, NE2 4AX, UK.
Daniel StevensCentre for Bacterial Cell Biology, Biosciences Institute, Newcastle University, Newcastle Upon Tyne, NE2 4AX, UK.ORCID 0000-0002-5306-8864
Charles WinterhalterCentre for Bacterial Cell Biology, Biosciences Institute, Newcastle University, Newcastle Upon Tyne, NE2 4AX, UK.ORCID 0000-0001-9673-1227
Frederic D SchrammCentre for Bacterial Cell Biology, Biosciences Institute, Newcastle University, Newcastle Upon Tyne, NE2 4AX, UK.ORCID 0000-0003-1858-7770
Sara PintarCentre for Bacterial Cell Biology, Biosciences Institute, Newcastle University, Newcastle Upon Tyne, NE2 4AX, UK.ORCID 0000-0002-9262-5360
Daniel R BurnhamThe Francis Crick Institute, 1 Midland Road, London, NW1 1AT, UK.
George MercesCentre for Bacterial Cell Biology, Biosciences Institute, Newcastle University, Newcastle Upon Tyne, NE2 4AX, UK.
Tomas T RichardsonCentre for Bacterial Cell Biology, Biosciences Institute, Newcastle University, Newcastle Upon Tyne, NE2 4AX, UK.ORCID 0009-0008-0743-1133
Yumiko TashiroCentre for Molecular Cell Biology, School of Biological and Behavioural Sciences, Queen Mary University of London, Newark Street, London, E1 2AT, UK.
Julia HubbardCentre for Bacterial Cell Biology, Biosciences Institute, Newcastle University, Newcastle Upon Tyne, NE2 4AX, UK.
Hasan YardimciThe Francis Crick Institute, 1 Midland Road, London, NW1 1AT, UK.ORCID 0000-0001-5009-1391
Aravindan IlangovanCentre for Molecular Cell Biology, School of Biological and Behavioural Sciences, Queen Mary University of London, Newark Street, London, E1 2AT, UK. a.ilangovan@qmul.ac.uk.ORCID 0000-0002-0391-3812
Heath MurrayCentre for Bacterial Cell Biology, Biosciences Institute, Newcastle University, Newcastle Upon Tyne, NE2 4AX, UK. heath.murray@newcastle.ac.uk.ORCID 0000-0002-6467-3656
Newcastle University · GBQueen Mary University of London · GBThe Francis Crick Institute · GB

Funding

Academy of Medical Sciences SBF007\100161Wellcome Trust FC001221
6 · The paper itself

Abstract

Genome duplication is essential for the proliferation of cellular life and this process is generally initiated by dedicated replication proteins at chromosome origins. In bacteria, DNA replication is initiated by the ubiquitous DnaA protein, which assembles into an oligomeric complex at the chromosome origin (oriC) that engages both double-stranded DNA (dsDNA) and single-stranded DNA (ssDNA) to promote DNA duplex opening. However, the mechanism of DnaA specifically opening a replication origin was unknown. Here we show that Bacillus subtilis DnaA

Indexed as

DNA-Binding ProteinsDNA ReplicationBacteriaBacterial ProteinsChromosomes, BacterialDNADNA, BacterialDNA, Single-StrandedReplication OriginBacterial ProteinsDNADNA, BacterialDNA-Binding ProteinsDNA, Single-Stranded

Identifiers

PMID38097584
PMCPMC10721633
OpenAlexW4389725470

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.