Evidence map›Paper›PMID 38097578›Full record

ArticleNature communications2023

Atherosclerotic plaque development in mice is enhanced by myeloid ZEB1 downregulation.

M C Martinez-Campanario, Marlies Cortés, Alazne Moreno-Lanceta, Lu Han, Chiara Ninfali, Verónica Domínguez, María J Andrés-Manzano, Marta Farràs, Anna Esteve-Codina, Carlos Enrich and 7 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

  1. Role of ZEB1 in angiogenesis and therapeutic potential (Review).International journal of molecular medicine · 2026
    Review
  2. Reprogramming macrophages to treat liver diseases.Hepatology (Baltimore, Md.) · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 8 institutions in 2 countries.

M C Martinez-CampanarioGroup of Gene Regulation in Stem Cells, Cell Plasticity, Differentiation, and Cancer, IDIBAPS, 08036, Barcelona, Spain.ORCID 0000-0002-2745-6505
Marlies Cortés *Group of Gene Regulation in Stem Cells, Cell Plasticity, Differentiation, and Cancer, IDIBAPS, 08036, Barcelona, Spain.ORCID 0000-0002-9313-1194
Alazne Moreno-Lanceta *Department of Biomedicine, University of Barcelona School of Medicine, 08036, Barcelona, Spain.
Lu HanGroup of Gene Regulation in Stem Cells, Cell Plasticity, Differentiation, and Cancer, IDIBAPS, 08036, Barcelona, Spain.ORCID 0000-0002-7527-4829
Chiara NinfaliGroup of Gene Regulation in Stem Cells, Cell Plasticity, Differentiation, and Cancer, IDIBAPS, 08036, Barcelona, Spain.
Verónica DomínguezTransgenesis Facility, National Center of Biotechnology (CNB) and Center for Molecular Biology Severo Ochoa (UAM-CBMSO), Spanish National Research Council (CSIC) and Autonomous University of Madrid (UAM), Cantoblanco, 28049, Madrid, Spain.
María J Andrés-ManzanoGroup of Molecular and Genetic Cardiovascular Pathophysiology, Spanish National Center for Cardiovascular Research (CNIC), 28029, Madrid, Spain.
Marta FarràsDepartment of Biochemistry and Molecular Biology, Institute of Biomedical Research Sant Pau, University Autonomous of Barcelona, 08041, Barcelona, Spain.
Anna Esteve-CodinaNational Center for Genomics Analysis (CNAG), 08028, Barcelona, Spain.
Carlos EnrichDepartment of Biomedicine, University of Barcelona School of Medicine, 08036, Barcelona, Spain.
Francisco J Díaz-CrespoDepartment of Pathology, Hospital General Universitario Gregorio Marañón, 28007, Madrid, Spain.
Belén PintadoTransgenesis Facility, National Center of Biotechnology (CNB) and Center for Molecular Biology Severo Ochoa (UAM-CBMSO), Spanish National Research Council (CSIC) and Autonomous University of Madrid (UAM), Cantoblanco, 28049, Madrid, Spain.
Joan C Escolà-GilDepartment of Biochemistry and Molecular Biology, Institute of Biomedical Research Sant Pau, University Autonomous of Barcelona, 08041, Barcelona, Spain.ORCID 0000-0001-9021-2485
Pablo García de FrutosCenter for Biomedical, Research Network in Cardiovascular Diseases (CIBERCV), Carlos III Health Institute, 28029, Madrid, Spain.ORCID 0000-0003-1547-1190
Vicente AndrésGroup of Molecular and Genetic Cardiovascular Pathophysiology, Spanish National Center for Cardiovascular Research (CNIC), 28029, Madrid, Spain.
Pedro Melgar-LesmesDepartment of Biomedicine, University of Barcelona School of Medicine, 08036, Barcelona, Spain.
Antonio PostigoGroup of Gene Regulation in Stem Cells, Cell Plasticity, Differentiation, and Cancer, IDIBAPS, 08036, Barcelona, Spain. idib412@recerca.clinic.cat.ORCID 0000-0003-4605-2634
Instituto de Salud Carlos III · ESCentre for Genomic Regulation · ESConsejo Superior de Investigaciones Científicas · ESCentro Nacional de Análisis Genómico · ESHospital General Universitario Gregorio Marañón · ESInstitució Catalana de Recerca i Estudis Avançats · ESSpanish Ovarian Cancer Research Group · ESUniversitat de Barcelona · ES

Funding

China Scholarship Council (CSC) 202208110041Government of Catalonia | Agència de Gestió d'Ajuts Universitaris i de Recerca (Agency for Management of University and Research Grants) 2017-SGR-1174 and 2021-SGR-01328Ministry of Economy and Competitiveness | Agencia Estatal de Investigación (Spanish Agencia Estatal de Investigación) PID2020-116338RB-I00Ministry of Economy and Competitiveness | Agencia Estatal de Investigación (Spanish Agencia Estatal de Investigación) RYC2018-0Z23971-I
6 · The paper itself

Abstract

Accumulation of lipid-laden macrophages within the arterial neointima is a critical step in atherosclerotic plaque formation. Here, we show that reduced levels of the cellular plasticity factor ZEB1 in macrophages increase atherosclerotic plaque formation and the chance of cardiovascular events. Compared to control counterparts (Zeb1

Indexed as

AtherosclerosisPlaque, AtheroscleroticAnimalsApolipoproteins EDown-RegulationHumansLipoproteins, LDLMaleMiceMice, Inbred C57BLMice, KnockoutZinc Finger E-box-Binding Homeobox 1Apolipoproteins ELipoproteins, LDLZEB1 protein, humanZEB1 protein, mouseZinc Finger E-box-Binding Homeobox 1

Identifiers

PMID38097578
PMCPMC10721632
OpenAlexW4389728306

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.