ArticleNature communications2023
Induced formation of primordial germ cells from zebrafish blastomeres by germplasm factors.
Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 31 citations in OpenAlex.
- Zebrafish relatives as models for functional comparative genetics and genomics.Nature reviews. Genetics · 2026Review
- Ultra-fast generation of all-female grass carp via transplantation of female germline stem cells into zebrafish.Science China. Life sciences · 2026Article
- Cell-autonomous control coupled with tissue context regulates the cessation of migration at the site of organ development.Development (Cambridge, England) · 2026Article
- Primordial Germ Cell Development in Teleosts: Their Origin, Fate and Role in Sex Determination.Stem cell reviews and reports · 2026Review
- Efficient recovery of zebrafish maternal-zygotic mutants from in vivo expanded and cryopreserved germline stem cells.Communications biology · 2026Article
- Knockout ofZoological research · 2026Article
- Cholecystokinin coordinates gonadotropin-dependent and independent pathways to orchestrate zebrafish gonadal development.Nature communications · 2026Article
- PGC-derived migrasomes couple PGC proliferation with migration.Nature communications · 2026Article
- BMP-Smad1/9 signaling plays a critical role in regulating zebrafish PGC proliferation.Nature communications · 2026Article
- Differences in Early Development between Parental Species and Asexual Hybrids forms of European Spined Loaches (GenusSexual development : genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation · 2026Article
- Cyprinid Juji (Gobiocypris rarus) as a model fish to study germ cell development and gonadal differentiation.Communications biology · 2025Article
- Article
- Regulation of Xvelo assembly by centrosomal proteins.iScience · 2025Article
- Chromatin remodeling and H3K4me3 depletion regulate germline specification from pluripotency.Stem cell research & therapy · 2025Article
- Article
- Intestinal DHA-PA-PG axis promotes digestive organ expansion by mediating usage of maternally deposited yolk lipids.Nature communications · 2024Article
- Dzip1 is dynamically expressed in the vertebrate germline and regulates the development of Xenopus primordial germ cells.Developmental biology · 2024Article
- Article
- A toast to a zebrafish germ cell induction cocktail.Science China. Life sciences · 2024Article
- Endogenous biosynthesis of docosahexaenoic acid (DHA) regulates fish oocyte maturation by promoting pregnenolone production.Zoological research · 2024Article
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
Abstract
The combination of genome editing and primordial germ cell (PGC) transplantation has enormous significance in the study of developmental biology and genetic breeding, despite its low efficiency due to limited number of donor PGCs. Here, we employ a combination of germplasm factors to convert blastoderm cells into induced PGCs (iPGCs) in zebrafish and obtain functional gametes either through iPGC transplantation or via the single blastomere overexpression of germplasm factors. Zebrafish-derived germplasm factors convert blastula cells of Gobiocypris rarus into iPGCs, and Gobiocypris rarus spermatozoa can be produced by iPGC-transplanted zebrafish. Moreover, the combination of genome knock-in and iPGC transplantation perfectly resolves the contradiction between high knock-in efficiency and early lethality during embryonic stages and greatly improves the efficiency of genome knock-in. Together, we present an efficient method for generating PGCs in a teleost, a technique that will have a strong impact in basic research and aquaculture.
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Registered trials
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