Evidence map›Paper›PMID 38097544›Full record

ArticleNature communications2023

Directing polymorph specific calcium carbonate formation with de novo protein templates.

Fatima A Davila-Hernandez, Biao Jin, Harley Pyles, Shuai Zhang, Zheming Wang, Timothy F Huddy, Asim K Bera, Alex Kang, Chun-Long Chen, James J De Yoreo and 1 more

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
4.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 40 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
  6. Inhibition of ice recrystallization with designed twistless helical repeat proteins.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  7. De novo design of metal-oxide templating proteins.bioRxiv : the preprint server for biology · 2025
    Article
  8. Thermodynamics of calcium binding to heparin: Implications of solvation and water structuring for polysaccharide biofunctions.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  9. Article
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Fatima A Davila-Hernandez *Department of Biochemistry, University of Washington, Seattle, WA, 98195, USA.
Biao Jin *Physical Sciences Division, Pacific Northwest National Laboratory, Richland, WA, 99352, USA. biao.jin@pnnl.gov.
Harley Pyles *Department of Biochemistry, University of Washington, Seattle, WA, 98195, USA.
Shuai ZhangPhysical Sciences Division, Pacific Northwest National Laboratory, Richland, WA, 99352, USA.ORCID 0000-0003-0170-6470
Zheming WangPhysical Sciences Division, Pacific Northwest National Laboratory, Richland, WA, 99352, USA.
Timothy F HuddyDepartment of Biochemistry, University of Washington, Seattle, WA, 98195, USA.
Asim K BeraDepartment of Biochemistry, University of Washington, Seattle, WA, 98195, USA.ORCID 0000-0001-9473-2912
Alex KangDepartment of Biochemistry, University of Washington, Seattle, WA, 98195, USA.
Chun-Long ChenPhysical Sciences Division, Pacific Northwest National Laboratory, Richland, WA, 99352, USA.ORCID 0000-0002-5584-824X
James J De YoreoPhysical Sciences Division, Pacific Northwest National Laboratory, Richland, WA, 99352, USA. James.DeYoreo@pnnl.gov.ORCID 0000-0002-9541-733X
David BakerDepartment of Biochemistry, University of Washington, Seattle, WA, 98195, USA. dabaker@uw.edu.ORCID 0000-0001-7896-6217
Pacific Northwest National Laboratory · USUniversity of Washington · USCenter for Infectious Disease Research · US

Funding

User Training and OutreachP30GM124165 · NIGMS · CORNELL UNIVERSITY · PI Nozomi Ando, J Christopher Fromme · 2018 to 2026
$34.2M
Department of Energy DE-SC0018940NIGMS NIH HHS P30 GM124165
6 · The paper itself

Abstract

Biomolecules modulate inorganic crystallization to generate hierarchically structured biominerals, but the atomic structure of the organic-inorganic interfaces that regulate mineralization remain largely unknown. We hypothesized that heterogeneous nucleation of calcium carbonate could be achieved by a structured flat molecular template that pre-organizes calcium ions on its surface. To test this hypothesis, we design helical repeat proteins (DHRs) displaying regularly spaced carboxylate arrays on their surfaces and find that both protein monomers and protein-Ca

Indexed as

Calcium CarbonateNanoparticlesCrystallizationIonsCalcium CarbonateIons

Identifiers

PMID38097544
PMCPMC10721895
OpenAlexW4389742424

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.