SynthesisThe European respiratory journal2024
Genome-wide association study of preserved ratio impaired spirometry (PRISm).
Abstract readMeta-Analysis
In one paragraph
Synthesis in The European respiratory journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Comprehensive application of artificial intelligence in preserved ratio impaired spirometry: A systematic literature review.PloS one · 2026Pooled it
- Preserved ratio impaired spirometry, plasma proteomics, and incident heart failure.Journal of advanced research · 2026Article
- Preserved Ratio Impaired Spirometry in Low- and Middle-Income Countries: An Emerging Cardiopulmonary Phenotype and Cardiovascular Risk-A Narrative Review.Life (Basel, Switzerland) · 2026Review
- Clinical characteristics and outcomes associated with preserved ratio impaired spirometry (PRISm) in Saudi Arabia.Frontiers in medicine · 2026Article
- Dietary and lifestyle oxidative balance, metabolic dysfunction, and preserved ratio impaired spirometry in Chinese adults: a hospital-based cross-sectional study.Frontiers in nutrition · 2026Article
- The joint association between inflammation and centripedal obesity with mortality risk in patients with preserved ratio impaired spirometry.NPJ primary care respiratory medicine · 2025Article
- Oscillometry findings in altered spirometry patterns and relationship to respiratory symptoms.ERJ open research · 2025Article
- Associations of preserved ratio impaired spirometry with cardiometabolic comorbidities: a systematic review and meta-analysis.ERJ open research · 2025Article
- Article
- Regional lung function assessment using electrical impedance tomography in COPD, PRISm, and normal spirometry subjects: insights into early diagnostic potential.BMC pulmonary medicine · 2025Article
- Identifying cross-tissue molecular targets of lung function by multi-omics integration analysis from DNA methylation and gene expression of diverse human tissues.BMC genomics · 2025Article
- Preserved ratio impaired spirometry: clinical, imaging and artificial intelligence perspective.Journal of thoracic disease · 2025Review
- PRISm: What's in a Name?American journal of respiratory and critical care medicine · 2024Article
- Reply to Jankowich: PRISm: What?s in a Name?American journal of respiratory and critical care medicine · 2024Article
- COPD, PRISm and lung function reduction affect the brain cortical structure: a Mendelian randomization study.BMC pulmonary medicine · 2024Article
- Pulmonary Function Tests: Easy Interpretation in Three Steps.Journal of clinical medicine · 2024Review
- Article
Corrections and comments
- Commented on by
Authors and funding
45 authors.
Daniel H HigbeeMRC Integrative Epidemiology Unit (IEU), University of Bristol, Bristol, UK.
Alvin LirioDepartment of Population Health Sciences, University of Leicester, Leicester, UK.
Fergus HamiltonMRC Integrative Epidemiology Unit (IEU), University of Bristol, Bristol, UK.
Raquel GranellMRC Integrative Epidemiology Unit (IEU), University of Bristol, Bristol, UK.
Annah B WyssEpidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA.
Stephanie J LondonEpidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA.ORCID 0000-0003-4911-5290
Traci M BartzCardiovascular Health Research Unit, Departments of Biostatistics and Medicine, University of Washington, Seattle, WA, USA.
Sina A GharibComputational Medicine Core, Center for Lung Biology, UW Medicine Sleep Center, Department of Medicine, University of Washington, Seattle, WA, USA.ORCID 0000-0002-2480-4367
Michael H ChoChanning Division of Network Medicine, Brigham and Women's Hospital, Boston, MA, USA.ORCID 0000-0002-4907-1657
Emily WanChanning Division of Network Medicine, Brigham and Women's Hospital, Boston, MA, USA.ORCID 0000-0002-4126-2467
Edwin SilvermanPulmonary and Critical Care Section, Department of Medicine, VA Boston Healthcare System, Boston, MA, USA.
James D CrapoDivision of Pulmonary, Critical Care and Sleep Medicine, National Jewish Health, Denver, CO, USA.
Jesus V T LomincharNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Torben HansenNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Niels GrarupNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Thomas DantoftCenter for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Frederiksberg, Denmark.
Line KårhusCenter for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Frederiksberg, Denmark.
Allan LinnebergCenter for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Frederiksberg, Denmark.
George T O'ConnorPulmonary Center, School of Medicine, Boston University, Boston, MA, USA.
Josée DupuisDepartment of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, QC, Canada.
Hanfie XuDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
Maaike M De VriesDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.ORCID 0000-0001-7210-8174
Xiaowei HuCenter for Public Health Genomics, University of Virginia, Charlottesville, VA, USA.
Stephen S RichCenter for Public Health Genomics, University of Virginia, Charlottesville, VA, USA.ORCID 0000-0003-3872-7793
R Graham BarrDepartment of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Ani ManichaikulCenter for Public Health Genomics, University of Virginia, Charlottesville, VA, USA.
Sara R A WijnantDepartment of Bioanalysis, Ghent University, Ghent, Belgium.ORCID 0000-0003-2995-0491
Guy G BrusselleDepartment of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium.ORCID 0000-0001-7021-8505
Lies LahousseDepartment of Bioanalysis, Ghent University, Ghent, Belgium.ORCID 0000-0002-3494-4363
Xuan LiCentre for Heart Lung Innovation, University of British Columbia, St. Paul's Hospital, Vancouver, BC, Canada.
Ana I Hernández CorderoCentre for Heart Lung Innovation, University of British Columbia, St. Paul's Hospital, Vancouver, BC, Canada.ORCID 0000-0002-5971-2526
Ma'en ObeidatCentre for Heart Lung Innovation, University of British Columbia, St. Paul's Hospital, Vancouver, BC, Canada.
Don D SinCentre for Heart Lung Innovation, University of British Columbia, St. Paul's Hospital, Vancouver, BC, Canada.
Sarah E HarrisLothian Birth Cohorts, Department of Psychology, University of Edinburgh, Edinburgh, UK.
Paul RedmondLothian Birth Cohorts, Department of Psychology, University of Edinburgh, Edinburgh, UK.
Adele M TaylorLothian Birth Cohorts, Department of Psychology, University of Edinburgh, Edinburgh, UK.
Simon R CoxLothian Birth Cohorts, Department of Psychology, University of Edinburgh, Edinburgh, UK.
Alexander T WilliamsDepartment of Population Health Sciences, University of Leicester, Leicester, UK.
Nick ShrineDepartment of Population Health Sciences, University of Leicester, Leicester, UK.ORCID 0000-0003-3641-4371
Catherine JohnDepartment of Population Health Sciences, University of Leicester, Leicester, UK.
Anna L GuyattDepartment of Population Health Sciences, University of Leicester, Leicester, UK.ORCID 0000-0003-1860-6337
Ian P HallUniversity of Nottingham and NIHR Nottingham Biomedical Research Centre, Nottingham, UK.
George Davey SmithMRC Integrative Epidemiology Unit (IEU), University of Bristol, Bristol, UK.ORCID 0000-0002-1407-8314
Martin D TobinDepartment of Population Health Sciences, University of Leicester, Leicester, UK.ORCID 0000-0002-3596-7874
James W DoddMRC Integrative Epidemiology Unit (IEU), University of Bristol, Bristol, UK james.dodd@bristol.ac.uk.ORCID 0000-0003-4805-5759
Funding
UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1MClinical and Translational Science AwardUL1TR001873 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI REILLY, MUREDACH P · 2016 to 2025
$99.0MInstitute for Clinical and Translational ResearchUL1TR001079 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$60.1MGenetic Epidemiology of COPDU01HL089897 · NHLBI · NATIONAL JEWISH HEALTH · PI CRAPO, JAMES D · 2007 to 2021
$56.9MTransgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MILES Frome WILKINSON · 2003 to 2026
$40.4MWake Forest Clinical and Translational Science AwardUL1TR001420 · NCATS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ARD, JAMY D, FOLEY, KRISTIE L · 2015 to 2023
$32.3MClinical and Translational Science AwardUL1TR000040 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2012 to 2015
$26.2MGenetic Epidemiology of COPDU01HL089856 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SILVERMAN, EDWIN K · 2007 to 2021
$20.7M(2 of 2) Genetic Epidemiology of COPDR01HL089856 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SILVERMAN, EDWIN K · 2012 to 2016
$18.9MPulmonary microvascular perfusion in the Multi-Ethnic Study of AtherosclerosisR01HL077612 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI R Graham BARR · 2004 to 2026
$18.8MPulmonary Vascular Changes in Early Chronic Obstructive Pulmonary Disease (COPD)R01HL093081 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI R Graham BARR · 2008 to 2026
$17.2MTask Area A Core Study Operations.Task Area A shall encompass annual follow-up of cohort members, clinical endpoints ascertainment, study coordination activities, maintenance of the database and biosp75N92020D00001 · NHLBI · UNIVERSITY OF WASHINGTON · PI MCCLELLAND, ROBYN LEAGH · 2020 to 2025
$17.2MIntramural NIH HHS Z01 CP010119Intramural NIH HHS Z01 ES043012Intramural NIH HHS Z01 ES049030Medical Research Council G0902313Medical Research Council MC_PC_19004Medical Research Council MC_UU_00011/1Medical Research Council MC_UU_00032/1NCATS NIH HHS UL1 TR000040NCATS NIH HHS UL1 TR001079NCATS NIH HHS UL1 TR001420NCATS NIH HHS UL1 TR001873NCATS NIH HHS UL1 TR001881NHLBI NIH HHS 75N92020D00001NHLBI NIH HHS 75N92020D00002NHLBI NIH HHS 75N92020D00003NHLBI NIH HHS 75N92020D00004NHLBI NIH HHS 75N92020D00005NHLBI NIH HHS 75N92020D00006NHLBI NIH HHS 75N92020D00007NHLBI NIH HHS 75N92021D00006NHLBI NIH HHS HHSN268200800007CNHLBI NIH HHS HHSN268201200036CNHLBI NIH HHS HHSN268201500003CNHLBI NIH HHS HHSN268201500003INHLBI NIH HHS HHSN268201800001CNHLBI NIH HHS N01 HC055222NHLBI NIH HHS N01 HC085079NHLBI NIH HHS N01 HC085080NHLBI NIH HHS N01 HC085081NHLBI NIH HHS N01 HC085082NHLBI NIH HHS N01 HC085083NHLBI NIH HHS N01 HC085086NHLBI NIH HHS N01 HC095159NHLBI NIH HHS N01 HC095160NHLBI NIH HHS N01 HC095161NHLBI NIH HHS N01 HC095162NHLBI NIH HHS N01 HC095163NHLBI NIH HHS N01 HC095164NHLBI NIH HHS N01 HC095165NHLBI NIH HHS N01 HC095166NHLBI NIH HHS N01 HC095167NHLBI NIH HHS N01 HC095168NHLBI NIH HHS N01 HC095169NHLBI NIH HHS N02 HL064278NHLBI NIH HHS R01 HL077612NHLBI NIH HHS R01 HL087652NHLBI NIH HHS R01 HL089856NHLBI NIH HHS R01 HL093081NHLBI NIH HHS R01 HL103612NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01 HL120393NHLBI NIH HHS R01 HL142028NHLBI NIH HHS R01 HL153248NHLBI NIH HHS U01 HL080295NHLBI NIH HHS U01 HL089856NHLBI NIH HHS U01 HL089897NHLBI NIH HHS U01 HL130114NIA NIH HHS R01 AG023629NIDDK NIH HHS P30 DK063491NIEHS NIH HHS N01 ES055546Wellcome Trust 225221
Abstract
backgroundPreserved ratio impaired spirometry (PRISm) is defined as a forced expiratory volume in 1 s (FEV
methodsWe undertook a genome-wide association study (GWAS) of PRISm in UK Biobank participants (Stage 1), and selected single nucleotide polymorphisms (SNPs) reaching genome-wide significance for replication in 13 cohorts (Stage 2). A combined meta-analysis of Stage 1 and Stage 2 was done to determine top SNPs. We used cross-trait linkage disequilibrium score regression to estimate genome-wide genetic correlation between PRISm and pulmonary and extrapulmonary traits. Phenome-wide association studies of top SNPs were performed.
results22 signals reached significance in the joint meta-analysis, including four signals novel for lung function. A strong genome-wide genetic correlation (r
conclusionThis is the first GWAS to successfully identify SNPs associated with PRISm. Four of the signals, rs7652391 (nearest gene
Indexed as
Diabetes Mellitus, Type 2Pulmonary Disease, Chronic ObstructiveForced Expiratory VolumeGenome-Wide Association StudyHumansLungSpirometryVital Capacity
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.