ArticleNature2024
Structures, functions and adaptations of the human LINE-1 ORF2 protein.
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Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 95 papers.
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95citing papers in PubMed
44.5field-weighted citation impact, top 1% of its field
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Who cites it
95 citing papers in PubMed, 113 citations in OpenAlex.
- The therapeutic potential of transposable element activity modulation.EMBO molecular medicine · 2026Review
- Coincidence of L1 retrotransposition and DNA repair deficiency elicits synthetic lethality in S-phase mature neurons.iScience · 2026Article
- Viral mimicry escape as a necessary feature of malignant transformation.Nature reviews. Cancer · 2026Review
- cGAS-deficient mice display premature aging associated with derepression of LINE1 elements and inflammation.Nature aging · 2026Article
- SIRT1 Silences L1 Retrotransposons by Stabilizing Heterochromatin-Modifying Complexes.Aging cell · 2026Article
- LINE-1 Epigenetic Repression and Regulation of Immunity.Viruses · 2026Review
- Transposable Element Activation: A Hallmark of Cancer.Cancer discovery · 2026Review
- LINE-1 insertion intermediates recombine with one another or with DNA breaks to form genome rearrangements.Nature communications · 2026Article
- Protein Data Bank (PDB) Archive: a new architecture (beta) for scalable, PDBx/mmCIF-based data distribution.Acta crystallographica. Section D, Structural biology · 2026Article
- Substrate and target selectivity of 4'-fluoroadenosine against viral and host polymerases.The Journal of biological chemistry · 2026Article
- High Throughput Characterization of Eukaryotic 2A-Like Peptides Identifies Novel Leucine-Associated Reduction in Protein Abundance.bioRxiv : the preprint server for biology · 2026Article
- LINE-1 Retrotransposons and Amyotrophic Lateral Sclerosis.International journal of molecular sciences · 2026Review
- Detection of endogenous LINE-1 ORF2p and its potent reverse transcriptase activity in the MCF-7 breast cancer cell line.The FEBS journal · 2026Article
- Testing the reliability of AI-generated protein structures.bioRxiv : the preprint server for biology · 2026Article
- Long-Standing Activity with Characteristic Genomic Insertion Signatures in Reptilian Bov-B LINEs and Associated Sauria SINEs.Biology · 2026Article
- Diploid dual assemblies reveal the telocentric structure and extensive allelic heterogeneity of canine genomes.NAR genomics and bioinformatics · 2026Article
- Locus-specific LINE-1 mRNA expression reflects cell-type- and stimulus-specific senescence states.Nucleic acids research · 2026Article
- Comparative genomics reveals LINE-1 recombination with diverse RNAs.Cell genomics · 2026Article
- Viral Mimicry of Alzheimer's Disease: Innate Sensing of Self-Nucleic Acids as a Driver of Glial Senescence.Journal of molecular neuroscience : MN · 2026Review
- Pervasive enhanced transcription in inflammatory breast cancer tumors and PBMCs impacts RNA splicing and intronic RNAs in plasma.Science advances · 2026Article
35 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
45 authors at 14 institutions in 6 countries.
Eric T Baldwin *ROME Therapeutics, Boston, MA, USA.
Trevor van Eeuwen *Laboratory of Cellular and Structural Biology, The Rockefeller University, New York, NY, USA.ORCID 0000-0003-0549-1702
David Hoyos *Computational Oncology, Department of Epidemiology & Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Arthur Zalevsky *Department of Bioengineering and Therapeutic Sciences University of California, San Francisco, San Francisco, CA, USA.ORCID 0000-0001-6987-8119
Egor P TchesnokovDepartment of Medical Microbiology and Immunology, University of Alberta, Edmonton, Alberta, Canada.
Roberto SánchezROME Therapeutics, Boston, MA, USA.
Bryant D MillerDepartment of Pathology, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA, USA.ORCID 0009-0006-9145-8499
Luciano H Di StefanoEuropean Research Institute for the Biology of Ageing, University Medical Center Groningen, Groningen, The Netherlands.
Francesc Xavier RuizCenter for Advanced Biotechnology and Medicine and Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, NJ, USA.ORCID 0000-0002-0457-0030
Matthew HancockDepartment of Bioengineering and Therapeutic Sciences University of California, San Francisco, San Francisco, CA, USA.
Esin IşikDepartment of Pathology, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA, USA.
Carlos Mendez-DorantesDepartment of Pathology, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-8190-8568
Thomas WalpoleCharles River Laboratories, Chesterford Research Park, Saffron Walden, UK.
Charles NicholsCharles River Laboratories, Chesterford Research Park, Saffron Walden, UK.
Paul WanCharles River Laboratories, Chesterford Research Park, Saffron Walden, UK.
Kirsi RientoCharles River Laboratories, Chesterford Research Park, Saffron Walden, UK.
Rowan Halls-KassCharles River Laboratories, Chesterford Research Park, Saffron Walden, UK.
Martin AugustinProteros Biostructures GmbH, Martinsried, Planegg, Germany.
Alfred LammensProteros Biostructures GmbH, Martinsried, Planegg, Germany.
Anja JestelProteros Biostructures GmbH, Martinsried, Planegg, Germany.
Paula UplaLaboratory of Cellular and Structural Biology, The Rockefeller University, New York, NY, USA.
Kera XibinakuWhitehead Institute for Biomedical Research, Cambridge, MA, USA.
Samantha CongreveWhitehead Institute for Biomedical Research, Cambridge, MA, USA.ORCID 0009-0001-5277-2235
Maximiliaan HenninkWhitehead Institute for Biomedical Research, Cambridge, MA, USA.ORCID 0009-0000-1589-1780
Kacper B RogalaDepartment of Structural Biology, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0001-5997-7770
Anna M SchneiderStructural Biology of Selfish RNA, Department of Protein Evolution, Max Planck Institute for Biology, Tübingen, Germany.
Jennifer E FairmanJohns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0002-2319-1773
Shawn M ChristensenDepartment of Biology, University of Texas at Arlington, Arlington, TX, USA.
Brian DesrosiersROME Therapeutics, Boston, MA, USA.
Gregory S BisacchiROME Therapeutics, Boston, MA, USA.
Oliver L SaundersROME Therapeutics, Boston, MA, USA.
Nafeeza HafeezROME Therapeutics, Boston, MA, USA.
Wenyan MiaoROME Therapeutics, Boston, MA, USA.
Rosana KapellerROME Therapeutics, Boston, MA, USA.
Dennis M ZallerROME Therapeutics, Boston, MA, USA.
Andrej SaliDepartment of Bioengineering and Therapeutic Sciences University of California, San Francisco, San Francisco, CA, USA.ORCID 0000-0003-0435-6197
Oliver WeichenriederStructural Biology of Selfish RNA, Department of Protein Evolution, Max Planck Institute for Biology, Tübingen, Germany.ORCID 0000-0001-5818-6248
Kathleen H BurnsDepartment of Pathology, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA, USA. kathleenh_burns@dfci.harvard.edu.ORCID 0000-0003-1620-3761
Matthias GötteDepartment of Medical Microbiology and Immunology, University of Alberta, Edmonton, Alberta, Canada. gotte@ualberta.ca.ORCID 0000-0001-6213-5806
Michael P RoutLaboratory of Cellular and Structural Biology, The Rockefeller University, New York, NY, USA. rout@rockefeller.edu.ORCID 0000-0003-2010-706X
Eddy ArnoldCenter for Advanced Biotechnology and Medicine and Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, NJ, USA. arnold@cabm.rutgers.edu.ORCID 0000-0003-2612-9622
Benjamin D GreenbaumComputational Oncology, Department of Epidemiology & Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA. greenbab@mskcc.org.ORCID 0000-0001-6153-8793
Donna L RomeroROME Therapeutics, Boston, MA, USA. dlromero@rometx.com.ORCID 0000-0002-3009-1965
John LaCavaLaboratory of Cellular and Structural Biology, The Rockefeller University, New York, NY, USA. j.p.lacava@rug.nl.ORCID 0000-0002-6307-7713
Martin S Taylor *Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. mstaylor@mgh.harvard.edu.ORCID 0000-0003-1560-9276
Charles River Laboratories (United Kingdom) · GBHarvard University · USQB3 · USRockefeller University · USWhitehead Institute for Biomedical Research · USMax Planck Institute for Biology · DEMemorial Sloan Kettering Cancer Center · USRutgers, The State University of New Jersey · USUniversity Medical Center Groningen · NLUniversity of Alberta · CAJohns Hopkins University · USStanford University · USThe University of Texas at Arlington · USXerox (France) · FR
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4MNCCAT: National Center for CryoEM Access and Training- Supplement for Windows 10 and FFIU24GM129539 · NIGMS · NEW YORK STRUCTURAL BIOLOGY CENTER · PI DE MARCO, ALEX, KIEFT, JEFFREY S · 2018 to 2023
$53.9MSomatic Activation of Retrotransposition: A New Molecular Mechanism of Aging?P01AG051449 · NIA · BROWN UNIVERSITY · PI STEPHEN L HELFAND · 2016 to 2026
$30.4MTR&D Project 4. The Imaging Stage: Multiscale Spatiotemporal Modeling of Macromolecular Systems in Cellular NeighborhoodsP41GM109824 · NIGMS · ROCKEFELLER UNIVERSITY · PI ROUT, MICHAEL P · 2014 to 2023
$18.8MMOLECULAR IMMUNOLOGY AND TUMOR BIOLOGYT32CA009216 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI David Michael Langenau · 1985 to 2026
$10.6MIMP: Software for Hybrid Determination of Macromolecular Assembly StructuresR01GM083960 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SALI, ANDREJ · 2008 to 2024
$5.2MModulating anti-HIV immunity by plasmacytoid dendritic cellsR01AI081848 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI BHARDWAJ, NINA · 2010 to 2021
$4.5MSTRUCTURES OF HIV REVERSE TRANSCRIPTASE WITH SUBSTRATESR01AI027690 · NIAID · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI EDWARD ARNOLD · 1989 to 2026
$4.3MDefining molecular contributions of LINE-1 retrotransposons to AD / ADRDR01AG078925 · NIA · ROCKEFELLER UNIVERSITY · PI John LaCava, John M Sedivy · 2022 to 2026
$3.7MUnderstanding the Relationship of Repeat Expression and MetastasisR01CA240924 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI GREENBAUM, BENJAMIN, TING, DAVID TSAI · 2019 to 2023
$3.3MA Statistical Physics Framework for Understanding the Role of Repeat RNA in Tumor ImmunityU01CA228963 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI GREENBAUM, BENJAMIN, TING, DAVID TSAI · 2020 to 2024
$3.2MDemonstrating interactome-level connections between Alzheimer disease, LINE-1 retrotransposons, and cellular senescenceR01GM126170 · NIGMS · ROCKEFELLER UNIVERSITY · PI LACAVA, JOHN · 2018 to 2021
$2.4MNCI NIH HHS P30 CA008748NCI NIH HHS R01 CA240924NCI NIH HHS T32 CA009216NCI NIH HHS U01 CA228963NIAID NIH HHS R01 AI027690NIAID NIH HHS R01 AI081848NIA NIH HHS P01 AG051449NIA NIH HHS R01 AG078925NIDDK NIH HHS K08 DK129824NIGMS NIH HHS P41 GM109824NIGMS NIH HHS R01 GM083960NIGMS NIH HHS R01 GM126170NIGMS NIH HHS R01 GM130680NIGMS NIH HHS T32 GM149436NIGMS NIH HHS U24 GM129539
Abstract
The LINE-1 (L1) retrotransposon is an ancient genetic parasite that has written around one-third of the human genome through a 'copy and paste' mechanism catalysed by its multifunctional enzyme, open reading frame 2 protein (ORF2p)
Indexed as
EndonucleasesLong Interspersed Nucleotide ElementsReverse TranscriptionRNA-Directed DNA PolymeraseCryoelectron MicroscopyCrystallography, X-RayCyclic Guanosine Monophosphate-Adenosine Monophosphate SynthaseDNAHumansImmunity, InnateInterferonsRNASTING ProteincGAS protein, humanCyclic Guanosine Monophosphate-Adenosine Monophosphate SynthaseDNAEndonucleasesInterferonsORF2 protein, humanRNARNA-Directed DNA PolymeraseSTING1 protein, humanSTING Protein
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