Evidence map›Paper›PMID 38096758›Full record

ReviewCurrent opinion in neurobiology2024

Sensory alterations in post-traumatic stress disorder.

Leland L Fleming, Nathaniel G Harnett, Kerry J Ressler

Abstract readReview
In one paragraph

Review in Current opinion in neurobiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Somatic symptoms and sensory dysregulation are central to the clinical presentation of PTSD.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2026
    Article
  6. Post-traumatic stress disorder.Nature reviews. Disease primers · 2026
    Review
  7. Sensory hyperacusis as a predictor of anxiety in adolescence.Journal of child psychology and psychiatry, and allied disciplines · 2026
    Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Merkel cell stimulation in fear and sensory signaling.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025
    Article
  20. Stress-Related Brain Alterations in Chronic Pain.European journal of pain (London, England) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Leland L FlemingDivision of Depression and Anxiety, McLean Hospital, Belmont, USA; Department of Psychiatry, Harvard Medical School, Boston, USA.
Nathaniel G HarnettDivision of Depression and Anxiety, McLean Hospital, Belmont, USA; Department of Psychiatry, Harvard Medical School, Boston, USA.
Kerry J ResslerDivision of Depression and Anxiety, McLean Hospital, Belmont, USA; Department of Psychiatry, Harvard Medical School, Boston, USA. Electronic address: kressler@mclean.harvard.edu.

Funding

Cell Type Specific Genomic and Functional Dissection of Fear-Off Amygdala PathwaysR01MH108665 · NIMH · MCLEAN HOSPITAL · PI BOLSHAKOV, VADIM, RESSLER, KERRY J. · 2016 to 2025
$7.5M
Multimodal characterization of affective visual processing in the early aftermath of traumaK01MH129828 · NIMH · MCLEAN HOSPITAL · PI Nathaniel G Harnett · 2023 to 2026
$719k
Transgenerational Impact of Childhood Maltreatment on Structural/Functional Properties of Visual CortexK00HD111352 · NICHD · MCLEAN HOSPITAL · PI FLEMING, LELAND · 2022 to 2025
$359k
NICHD NIH HHS K00 HD111352NIMH NIH HHS K01 MH129828NIMH NIH HHS R01 MH108665
6 · The paper itself

Abstract

PTSD is characterized by difficulties in accurately evaluating the threat value of sensory stimuli. While the role of canonical fear and threat neural circuitry in this ability has been well studied, recent lines of evidence suggest a need to include more emphasis on sensory processing in the conceptualization of PTSD symptomology. Specifically, studies have demonstrated a strong association between variability in sensory processing regions and the severity of PTSD symptoms. In this review, we summarize recent findings that underscore the importance of sensory processing in PTSD, in addition to the structural and functional characteristics of associated sensory brain regions. First, we discuss the link between PTSD and various behavioral aspects of sensory processing. This is followed by a discussion of recent findings that link PTSD to variability in the structure of both gray and white matter in sensory brain regions. We then delve into how brain activity (measured with task-based and resting-state functional imaging) in sensory regions informs our understanding of PTSD symptomology.

Indexed as

Stress Disorders, Post-TraumaticBrainBrain MappingFearHumansMagnetic Resonance Imaging

Identifiers

PMID38096758
PMCPMC10922208

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.