Observational studyPloS one2023
An observational, multicenter, registry-based cohort study of Turkish Neonatal Society in neonates with Hypoxic ischemic encephalopathy.
Observational study in PloS one, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 20 citations in OpenAlex.
- Comparison of KDIGO and nRIFLE criteria for acute kidney injury in neonates with hypoxic-ischemic encephalopathy.Pediatric nephrology (Berlin, Germany) · 2026Article
- Neonatal encephalopathy mortality rate in Aotearoa, New Zealand: review of national data 2010-2020.BMJ paediatrics open · 2026Article
- Harnessing a neonatal encephalopathy registry for regional quality improvement efforts.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Long-Term Neurodevelopmental Outcomes and Prognostic Factors in Neonates with Hypoxic-Ischemic Encephalopathy.Journal of clinical medicine · 2026Article
- Observational
- Expert Consensus Approach to Developing Inpatient Common Data Elements for Neonatal Encephalopathy Research.Neurology · 2026Article
- From differential to definitive: diagnosing and treatment of neonatal encephalopathy.Pediatric research · 2025Article
- Complexin 2 contributes to the protective effect of NADActa pharmacologica Sinica · 2025Article
- Challenging Mild Hypoxic-Ischemic Encephalopathy: Insights Into Neurological Outcomes.Turkish archives of pediatrics · 2025Article
- Brain Injury Patterns and Short-TermOutcomes in Late Preterm Infants Treated with Hypothermia for Hypoxic Ischemic Encephalopathy.Children (Basel, Switzerland) · 2025Article
- Nanoparticle-mediated sodium butyrate delivery for repairing hypoxic-ischemic brain injury in premature infants.Materials today. Bio · 2025Article
- Long-Term Neonatal EEG Modeling with DSP and ML for Grading Hypoxic-Ischemic Encephalopathy Injury.Sensors (Basel, Switzerland) · 2025Article
- Data Collection Variability Across Neonatal Hypoxic-Ischemic Encephalopathy Registries.The Journal of pediatrics · 2025Article
- Therapeutic hypothermia for neonates: a bibliometric analysis and visualization research.Frontiers in neurology · 2025Article
- Enteral Nutrition in Newborns with Hypoxic-Ischemic Encephalopathy Undergoing Therapeutic Hypothermia.Sisli Etfal Hastanesi tip bulteni · 2025Article
- aEEG Assessment for Short-Term Outcome Prognosis Prediction in Hypoxic-Ischemic Encephalopathy: An 11-Year Experience.Sisli Etfal Hastanesi tip bulteni · 2025Article
- Effects of Therapeutic Hypothermia and Minimal Enteral Nutrition on Short-Term Outcomes in Neonates with Hypoxic-Ischemic Encephalopathy: A 10-Year Experience from Oman.Children (Basel, Switzerland) · 2024Article
- The Relationship between the Improvement Level in Blood Gas Parameters in Time and Brain MRI Findings in Newborns with the Diagnosis of Hypoxic Ischemic Encephalopathy.Turkish archives of pediatrics · 2024Article
- Labor management and neonatal outcomes in cardiotocography categories II and III (Review).Medicine internationalReview
Corrections and comments
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Authors and funding
63 authors at 20 institutions in 6 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHypoxic ischemic encephalopathy (HIE) is a significant cause of mortality and short- and long-term morbidities. Therapeutic hypothermia (TH) has been shown to be the standard care for HIE of infants ≥36 weeks gestational age (GA), as it has been demonstrated to reduce the rates of mortality, and adverse neurodevelopmental outcomes. This study aims to determine the incidence of HIE in our country, to assess the TH management in infants with HIE, and present short-term outcomes of these infants.
methodsThe Turkish Hypoxic Ischemic Encephalopathy Online Registry database was established for this multicenter, prospective, observational, nationally-based cohort study to evaluate the data of infants born at ≥34 weeks GA who displayed evidence of neonatal encephalopathy (NE) between March, 2020 and April 2022.
resultsThe incidence of HIE among infants born at ≥36 weeks GA (n = 965) was 2.13 per 1000 live births (517:242440), and accounting for 1.55% (965:62062) of all neonatal intensive care unit admissions. The rates of mild, moderate and severe HİE were 25.5% (n = 246), 58.9% (n = 568), and 15.6% (n = 151), respectively. Infants with severe HIE had higher rates of abnormal magnetic resonance imaging (MRI) findings, and mortality (p<0.001). No significant difference in mortality and abnormal MRI results was found according to the time of TH initiation (<3 h, 3-6 h and >6 h) (p>0.05). TH was administered to 85 (34.5%) infants with mild HIE, and of those born of 34-35 weeks of GA, 67.4% (n = 31) received TH. A total of 58 (6%) deaths were reported with a higher mortality rate in infants born at 34-35 weeks of GA (OR 3.941, 95% Cl 1.446-10.7422, p = 0.007).
conclusionThe incidence of HIE remained similar over time with a reduction in mortality rate. The timing of TH initiation, whether <3 or 3-6 h, did not result in lower occurrences of brain lesions on MRI or mortality. An increasing number of infants with mild HIE and late preterm infants with HIE are receiving TH; however, the indications for TH require further clarification. Longer follow-up studies are necessary for this vulnerable population.
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