Evidence map›Paper›PMID 38096180›Full record

ArticlePloS one2023

Improving the availability of antihypertensive drugs in the India Hypertension Control Initiative, India, 2019-2020.

Abhishek Kunwar, Prabhdeep Kaur, Kiran Durgad, Ganeshkumar Parasuraman, Meenakshi Sharma, Sudhir Gupta, Balram Bhargava, "India Hypertension Control Initiative (IHCI) collaboration

Open access · goldAbstract read
In one paragraph

Article in PloS one, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
9.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Abhishek KunwarDept of Noncommunicable Diseases, WHO Country Office for India, New Delhi, India.
Prabhdeep KaurDivision of Noncommunicable Diseases, ICMR-National Institute of Epidemiology, Chennai, India.ORCID 0000-0002-2605-3739
Kiran DurgadDept of Noncommunicable Diseases, WHO Country Office for India, New Delhi, India.
Ganeshkumar ParasuramanDivision of Noncommunicable Diseases, ICMR-National Institute of Epidemiology, Chennai, India.
Meenakshi SharmaIndian Council of Medical Research (ICMR), New Delhi, India.
Sudhir GuptaDirectorate General of Health Services, Ministry and Health, and Family Welfare, New Delhi, India.
Balram BhargavaIndian Council of Medical Research (ICMR), New Delhi, India.
"India Hypertension Control Initiative (IHCI) collaboration
Indian Council of Medical Research · INNational Institute of Epidemiology · INWorld Health Organization - India · INMinistry of Health and Family Welfare · IN

Funding

World Health Organization 001
6 · The paper itself

Abstract

backgroundAntihypertensive drug supply is sometimes inadequate in public sector health facilities in India. One of the core strategies of the India Hypertension Control Initiative (IHCI) is to improve the availability of antihypertensive drugs in primary and secondary care facilities. We quantified the availability of antihypertensive drugs in 2019-20 and described the practices in supply chain management in 22 districts across four states of India.

methodsTwenty-two districts from 4 states (Punjab, Madhya Pradesh, Telangana, and Maharashtra) were studied. We described the practices and challenges in supply chain management. We collected data on drug procurement from 2018 to 2020 and drug availability from April 2019 to March 2020. Quantity procured, the proportion of facilities with stockout at the end of each quarter, and availability of drugs in patient days were tabulated.

resultsAll states selected drug- and dose-specific protocols with Amlodipine as the initial drug and shifted to morbidity-based forecasting. The total number of antihypertensive tablets procured for the 22 districts increased from 16 million in 2017-2018 to 160 million in 2019-2020. The proportion of facilities with Amlodipine stock-out was below 5% during the study period. Amlodipine stock was available for at least 60 patient days from the third quarter of 2019 onward in all districts.

conclusionsThis study demonstrates that including best practices can gradually strengthen the procurement and supply chain for antihypertensives in a low-resource setting. As the program was rapidly growing, there were still gaps in the procurement and distribution system which needed to be addressed to ensure the adequacy of drugs. We recommend that best practices, including choosing a single protocol, basing supply on projected patient load rather than an increment from historical levels, and using simple stock management tools, be replicated in other districts in India to increase and sustain coverage of hypertension treatment.

Indexed as

Antihypertensive AgentsHypertensionAmlodipineHumansIndiaAmlodipineAntihypertensive Agents

Identifiers

PMID38096180
PMCPMC10721057
OpenAlexW4389726045

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.