Evidence map›Paper›PMID 38095675›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2024

[

Bastien Allard, Valérie Devauchelle-Pensec, Alain Saraux, Emmanuel Nowak, Alice Tison, Sara Boukhlal, Dewi Guellec, Sandrine Jousse-Joulin, Divi Cornec, Thierry Marhadour and 3 more

Registry-linked trialAbstract read
PubMed Publisher
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03632187 (To Demonstrate the Ability of Abatacept in Comparison to Placebo to Obtain a Low Disease Activity [PMR-AS), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03632187 phase3completednot on this map

To Demonstrate the Ability of Abatacept in Comparison to Placebo to Obtain a Low Disease Activity [PMR-AS (CRP) Lower or Equal to 10] Without GCs (Prednisone or Prednisolone) at Week 12 in Early Onset PMR Patients.

TypeinterventionalSponsorUniversity Hospital, BrestRan2018 to 2022Enrolled34ConditionsPolymyalgia RheumaticaArmsAbatacept, Placebos
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Review
  3. Whole-body and site specific [EJNMMI research · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Bastien AllardNuclear Medicine Department, University Hospital, Brest, France.
Valérie Devauchelle-PensecUniversity of Western Brittany (UBO), Brest, France.
Alain SarauxUniversity of Western Brittany (UBO), Brest, France.
Emmanuel NowakClinical Research and Innovation Department (DRCI), INSERM CIC 0502, Brest University Hospital, Brest, France.
Alice TisonUniversity of Western Brittany (UBO), Brest, France.
Sara BoukhlalUniversity of Western Brittany (UBO), Brest, France.
Dewi GuellecUniversity of Western Brittany (UBO), Brest, France.
Sandrine Jousse-JoulinUniversity of Western Brittany (UBO), Brest, France.
Divi CornecUniversity of Western Brittany (UBO), Brest, France.
Thierry MarhadourUniversity of Western Brittany (UBO), Brest, France.
Romain Le PennecNuclear Medicine Department, University Hospital, Brest, France.
Pierre-Yves SalaünNuclear Medicine Department, University Hospital, Brest, France.
Solène QuerellouNuclear Medicine Department, University Hospital, Brest, France. solene.querellou@chu-brest.fr.ORCID 0000-0002-4525-2696
Inserm · FRUniversité de Bretagne Occidentale · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeEvaluate the benefit of 2-deoxy-2-[18F]-fluoro-D-glucose ([

methodsThis was an ancillary study of ALORS trial (Abatacept in earLy Onset polymyalgia Rheumatica Study) assessing the ability of ABA versus placebo to achieve low disease activity (C-Reactive Protein PMR activity score (CRP PMR-AS) ≤ to 10) without glucocorticoid (GC) at week 12 in patients with early-onset PMR. The patients underwent [

resultsAt W12, there was no significant difference according to SUVmax between the ABA and the placebo groups in all ROI. Subgroup analysis according to GC administration demonstrated a significant (p 0.047) decrease in SUVmax within the left sternoclavicular joint ROI in the ABA group (- 0.8) compared to the placebo group (+ 0.6) without GC rescue. Other results did not reveal any significant difference between the ABA and placebo groups. According to combined qualitative scores, there was no significant difference between ABA and placebo groups for the direct comparison analysis and subgroup analysis according to GC rescue.

conclusion[ CLINICAL

trial registrationThe study was approved by the appropriate ethics committee (CPP Sud-Est II Ref CPP: 2018-33), and all patients gave their written informed consent before study enrollment. The protocol was registered on Clinicaltrials.gov (NCT03632187).

Indexed as

Giant Cell ArteritisPolymyalgia RheumaticaSulfonamidesAbataceptFluorodeoxyglucose F18HumansPositron Emission Tomography Computed TomographyAbataceptFluorodeoxyglucose F18SulfonamidesW 12[18F] FDG PET/CTAbataceptInflammationPolymyalgia rheumaticaSteroidsTherapeutic assessment

Identifiers

PMID38095675
OpenAlexW4389738269

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.