Evidence map›Paper›PMID 38095673›Full record

Observational studyEuropean journal of nuclear medicine and molecular imaging2024

Comparative assessment of radiation therapy-induced vasculitis using [

D Evanson, M Griffin, S E O'Reilly, T Johnson, T Werner, E Kothekar, P Jahangiri, C B Simone, S Swisher-McClure, S J Feigenberg and 3 more

Registry-linked trialOpen access · hybridAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in European journal of nuclear medicine and molecular imaging, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02135679 (The Detection Of Circulating Tumor Cells), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02135679 completednot on this map

The Detection Of Circulating Tumor Cells (CTC) In Patients With Non-small Cell Lung Cancer (NSCLC) Undergoing Definitive Radiotherapy Or Chemoradiotherapy

TypeobservationalSponsorAbramson Cancer Center at Penn MedicineRan2012 to 2021Enrolled204ConditionsNon-small Cell Lung CancerArmsRadiotherapy
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Delayed total-body [European journal of nuclear medicine and molecular imaging · 2026
    Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

D EvansonDrexel University College of Medicine, Philadelphia, PA, USA.
M GriffinDrexel University College of Medicine, Philadelphia, PA, USA.
S E O'ReillyDepartment of Radiology, University of Pennsylvania, Philadelphia, PA, USA.
T JohnsonUniversity of Notre Dame, Notre Dame, IN, USA.
T WernerDepartment of Radiology, University of Pennsylvania, Philadelphia, PA, USA.
E KothekarDepartment of Radiology, University of Pennsylvania, Philadelphia, PA, USA.
P JahangiriDepartment of Radiology, University of Pennsylvania, Philadelphia, PA, USA.
C B SimoneNew York Proton Center, New York, NY, USA.
S Swisher-McClureDepartment of Radiology, University of Pennsylvania, Philadelphia, PA, USA.
S J FeigenbergDepartment of Radiology, University of Pennsylvania, Philadelphia, PA, USA.
M-E RevheimThe Intervention Center, Oslo University Hospital, Oslo, Norway. monar@ous-hf.no.
J ZouDepartment of Radiology, University of Pennsylvania, Philadelphia, PA, USA.
A AlaviDepartment of Radiology, University of Pennsylvania, Philadelphia, PA, USA.
University of Pennsylvania · USNew York Proton Center · USOslo University Hospital · NOUniversity of Notre Dame · US

Funding

SUMMER UNDERGRADUATE PROGRAM TO EDUCATE RADIATION SCIENTISTS (SUPERS)R25CA140116 · NCI · UNIVERSITY OF PENNSYLVANIA · PI JAY FITZGERALD DORSEY · 2010 to 2026
$4.1M
NCI NIH HHS R25 CA140116
6 · The paper itself

Abstract

purposeTo assess radiation therapy (RT)-induced vasculitis in patients with non-small cell lung cancer (NSCLC) by examining changes in the uptake of

methodThirty-five consecutive locally advanced NSCLC patients were definitively treated with proton (n = 27) or photon (n = 8) RT and concurrent chemotherapy. The patients were prospectively enrolled to undergo [

resultsRT treatments were associated with increased SUVmeans in the AA, DA, and AoA-1.9%, 0.3%, and 1.3% for proton and 15.8%, 9.5%, and 15.5% for photon, respectively. There was a statistically significant difference in the ∆SUVmean (post-RT SUVmean - pre-RT SUVmean) in patients treated with photon RT when compared to ∆SUVmean in patients treated with proton RT in the AA (p = 0.043) and AoA (p = 0.015). There was an average increase in SUVmean that was related to dose for photon patients (across structures), but that was not seen for proton patients, although the increase was not statistically significant.

conclusionOur results suggest that patients treated with photon RT for NSCLC may exhibit significantly more RT-induced inflammation (measured as ∆SUVmean) in the AA and AoA when compared to patients who received proton RT. Knowledge gained from further analyses in larger cohorts could aid in treatment planning and help prevent the significant morbidity and mortality associated with RT-induced vascular complications.

trial registrationNCT02135679.

Indexed as

Carcinoma, Non-Small-Cell LungLung NeoplasmsRadiation InjuriesVasculitisFluorodeoxyglucose F18HumansPositron-Emission TomographyPositron Emission Tomography Computed TomographyProtonsRadiopharmaceuticalsFluorodeoxyglucose F18ProtonsRadiopharmaceuticals[18F]FDG-PETPhoton radiotherapyProton radiotherapyRadiation therapyVasculitis

Identifiers

PMID38095673
PMCPMC10957676
OpenAlexW4389742553

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.