ArticleDiabetologia2024
Hyperglycaemia, diabetes and risk of fragility fractures: observational and Mendelian randomisation studies.
Article in Diabetologia, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- Association between type 2 diabetes and site-specific fracture risk: A systematic review and meta-analysis of cohort studies including over 13 million participants.Diabetic medicine : a journal of the British Diabetic Association · 2026Pooled it
- The Risk of Fractures in Patients with Type 1 Diabetes Mellitus.Journal of clinical medicine · 2026Article
- Integrative bioinformatics and machine learning reveal hub genes and immune signatures bridging type 2 diabetes mellitus, fracture susceptibility, and osteoblast differentiation dysfunction.Mammalian genome : official journal of the International Mammalian Genome Society · 2026Article
- A protein-based prediction model for fragility fracture risk in individuals with diabetes.Journal of molecular cell biology · 2026Article
- Article
- ApoA1 and ApoB Are Associated with Fracture Risk in Patients with Type 1 Diabetes.Journal of clinical medicine · 2026Article
- Association between frailty index and hip fracture among Chinese middle- and old-aged adults in different glycemic status: a prospective study from the China Health and Retirement Longitudinal Study (CHARLS).International journal of surgery (London, England) · 2026Article
- CT-based age-related trabecular redistribution in the proximal femur and its association with fracture patterns in elderly individuals with and without diabetes.Frontiers in endocrinology · 2026Article
- Age-specific association between moderate-to-vigorous physical activity and bone health: insights from a universal pDXA screening cohort in rural China.Frontiers in endocrinology · 2026Article
- Development and Validation of a Multivariable Prediction Model for Recurrent Osteoporotic Fractures in Elderly Patients With Type 2 Diabetes Mellitus: A Prospective Observational Study.Journal of osteoporosis · 2026Article
- Surgery-related factors associated with early postoperative kinesiophobia in geriatric hip fracture patients: a risk stratification model.Frontiers in medicine · 2026Article
- Unveiling Epigenetic Molecular Mechanisms in Bone Fracture Risk: Insights From 731 Immune Cells, 1400 Metabolites, and Critical Genetic Pathways.Mediators of inflammation · 2026Article
- Molecular mechanisms and preclinical evidence of natural products in diabetic osteoporosis: a review.Frontiers in endocrinology · 2026Review
- Degree of Joint Risk Factor Control and Incident Fracture Outcomes in Individuals With Type 2 Diabetes.The Journal of clinical endocrinology and metabolism · 2025Article
- Diabetic bone fragility through advanced glycation end product-collagen axis: Mechanisms and therapy of sodium glucose cotransporter 2 inhibitors.World journal of diabetes · 2025Review
- Early hip arthroplasty in elderly hip-fracture patients: a perspective from HbA1c.BMC geriatrics · 2025Article
- Effect of GIP and GLP-1 infusion on bone resorption in glucose intolerant, pancreatic insufficient cystic fibrosis.Journal of clinical & translational endocrinology · 2025Article
- Different Forms of Regulated Cell Death in Type-2-Diabetes-Mellitus-Related Osteoporosis: A Focus on Mechanisms and Therapeutic Strategies.International journal of molecular sciences · 2025Review
- New Evidence, Creative Insights, and Strategic Solutions: Advancing the Understanding and Practice of Diabetes Osteoporosis.Journal of diabetes · 2025Review
- PEX11B palmitoylation couples peroxisomal dysfunction with Schwann cells fail in diabetic neuropathy.Journal of biomedical science · 2025Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aims/hypothesisFragility fractures may be a complication of diabetes, partly caused by chronic hyperglycaemia. We hypothesised that: (1) individuals with hyperglycaemia and diabetes have increased risk of fragility fracture; (2) hyperglycaemia is causally associated with increased risk of fragility fracture; and (3) diabetes and fragility fracture jointly associate with the highest risk of all-cause mortality.
methodsIn total, 117,054 individuals from the Copenhagen City Heart Study and the Copenhagen General Population Study (the Copenhagen studies) and 390,374 individuals from UK Biobank were included for observational and one-sample Mendelian randomisation (MR) analyses. Fragility fractures were defined as fractures at the hip, spine and arm (humerus/wrist), collected from national health registries. Summary data for fasting glucose and HbA
resultsHigher fasting and non-fasting glucose and HbA CONCLUSIONS/
interpretationHyperglycaemia and diabetes are risk factors for fragility fracture and one- and two-sample MR analyses supported a causal effect of hyperglycaemia on arm fractures. Diabetes and previous fragility fracture jointly conferred the highest risk of death in the general population.
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