Evidence map›Paper›PMID 38095642›Full record

ArticleAging2023

Specific knockout of notch-1 attenuates non-alcoholic fatty liver disease by promoting SHP2 phosphorylation.

Qian Gao, Yonggang Lu, Weiling Zhou

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Qian GaoDepartment of Endocrine and Metabolic Diseases, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050000, China.
Yonggang LuClinical Laboratory, Hebei General Hospital, Shijiazhuang 050000, China.
Weiling ZhouDepartment of Endocrine and Metabolic Diseases, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050000, China.
Fourth Hospital of Hebei Medical University · CNHebei General Hospital · CNHebei Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate the effect of Notch-1 signaling on NAFLD and its molecular mechanism.

methodsThe lipid deposition in liver tissues was detected by oil red O staining. Western blotting was performed to detect the expressions of SREBP1C, SREBP2, LXR, IL-1β, IL-18, NLRP3, Notch-1, NOX2, NOX4, p-PI3K and p-SHP2 in macrophages, and the expressions of ALIX, CD9, IL-1β and SREBP1C in exosomes. Macrophages in the Notch-1

resultsIt was observed by oil red O staining that lipid deposition in mice with NAFLD was reduced in the Notch-1

conclusionSpecific knockout of Notch-1 attenuates NAFLD, and reduces inflammation and lipid deposition in the liver by promoting SHP2 phosphorylation.

Indexed as

Non-alcoholic Fatty Liver DiseaseRelaxinAnimalsAzo CompoundsInterleukin-18LipidsLiverMiceNLR Family, Pyrin Domain-Containing 3 ProteinPhosphatidylinositol 3-KinasesPhosphorylationProtein Tyrosine Phosphatase, Non-Receptor Type 11Receptor, Notch1Azo CompoundsInterleukin-18LipidsNLR Family, Pyrin Domain-Containing 3 ProteinNotch1 protein, mouseoil red OPhosphatidylinositol 3-KinasesProtein Tyrosine Phosphatase, Non-Receptor Type 11Ptpn11 protein, mouseReceptor, Notch1Relaxininflammationlipid depositionNAFLDNotch-1SHP2

Identifiers

PMID38095642
PMCPMC10756087
OpenAlexW4389685847

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.