Evidence map›Paper›PMID 38095513›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2024

A Lysosome-Targeted Magnetic Nanotorquer Mechanically Triggers Ferroptosis for Breast Cancer Treatment.

Xueyan Wei, Yingze Li, Haotian Chen, Rui Gao, Peng Ning, Yingying Wang, Wanxin Huang, Erzhen Chen, Lan Fang, Xingrong Guo and 2 more

Open access · goldAbstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 33 citations in OpenAlex.

  1. Article
  2. Spatiotemporal cancer controlNanomedicine (London, England) · 2026
    Review
  3. Review
  4. Review
  5. Article
  6. Peptide-functionalized nanoparticles for brain-targeted therapeutics.Drug delivery and translational research · 2026
    Review
  7. Article
  8. Metabolic Regulation of Ferroptosis in Breast Cancer.International journal of molecular sciences · 2025
    Review
  9. Review
  10. Article
  11. Review
  12. Article
  13. Article
  14. Review
  15. Article
  16. Mechanism of Ferroptosis and Its Role in Disease Development.International journal of biological sciences · 2025
    Review
  17. Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Xueyan WeiTranslational Research Institute of Brain and Brain-Like Intelligence, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai, 200092, China.
Yingze LiTranslational Research Institute of Brain and Brain-Like Intelligence, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai, 200092, China.
Haotian ChenTranslational Research Institute of Brain and Brain-Like Intelligence, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai, 200092, China.
Rui GaoTranslational Research Institute of Brain and Brain-Like Intelligence, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai, 200092, China.
Peng NingTranslational Research Institute of Brain and Brain-Like Intelligence, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai, 200092, China.
Yingying WangTranslational Research Institute of Brain and Brain-Like Intelligence, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai, 200092, China.
Wanxin HuangTranslational Research Institute of Brain and Brain-Like Intelligence, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai, 200092, China.
Erzhen ChenTranslational Research Institute of Brain and Brain-Like Intelligence, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai, 200092, China.
Lan FangShanghai Tenth People's Hospital, School of Medicine, Tongji University Cancer Center, Shanghai, 200072, China.
Xingrong GuoHubei Key Laboratory of Embryonic Stem Cell Research, Hubei Clinical Research Center for Umbilical Cord Blood Hematopoietic Stem Cells, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei, 442000, China.
Cheng LvTranslational Research Institute of Brain and Brain-Like Intelligence, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai, 200092, China.
Yu ChengTranslational Research Institute of Brain and Brain-Like Intelligence, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai, 200092, China.ORCID 0000-0002-9030-2023
Tongji University · CNHubei University of Medicine · CN

Funding

Fundamental Research Funds for the Central UniversitiesNational Key Research and Development Program of China 2021YFA1201400National Natural Science Foundation of China 22007073National Natural Science Foundation of China 82022039Science and Technology Commission Foundation of Shanghai 21XD1423900Shanghai Municipal Education Commission Innovative Program 2023ZKZD27Shanghai Pilot Program for Basic ResearchShanghai Sailing Program 20YF1452100The Project of Hubei Key Laboratory of Embryonic Stem Cell Research 2021ESOF002
6 · The paper itself

Abstract

Targeting ferroptosis has attracted exponential attention to eradicate cancer cells with high iron-dependent growth. Increasing the level of intracellular labile iron pool via small molecules and iron-containing nanomaterials is an effective approach to induce ferroptosis but often faces insufficient efficacy due to the fast drug metabolism and toxicity issues on normal tissues. Therefore, developing a long-acting and selective approach to regulate ferroptosis is highly demanded in cancer treatment. Herein, a lysosome-targeted magnetic nanotorquer (T7-MNT) is proposed as the mechanical tool to dynamically induce the endogenous Fe

Indexed as

Breast NeoplasmsFerroptosisFemaleHumansIronLysosomesMagnetic FieldsIroncancer treatmentferroptosis inducerlabile iron poolmagnetic nanotorquermechanical regulation

Identifiers

PMID38095513
PMCPMC10916606
OpenAlexW4389742960

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.