Evidence map›Paper›PMID 38095434›Full record

ArticleNeurosurgery2024

Dural Arteriovenous Fistulas With Cognitive Impairment: Angiographic Characteristics and Treatment Outcomes.

Sebastian Sanchez, Linder Wendt, Minako Hayakawa, Ching-Jen Chen, Jason P Sheehan, Louis J Kim, Isaac Josh Abecassis, Michael R Levitt, R Michael Meyer, Ridhima Guniganti and 28 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurosurgery, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. The Glymphatic System and Its Role in Neurovascular Diseases.Journal of neuroendovascular therapy · 2025
    Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

38 authors at 18 institutions in 4 countries.

Sebastian SanchezDepartment of Neurology, University of Iowa Hospitals and Clinics, Iowa City , Iowa , USA.
Linder WendtInstitute for Clinical and Translational Science, University of Iowa Hospitals and Clinics, Iowa City , Iowa , USA.
Minako HayakawaDepartment of Radiology, University of Iowa Hospitals and Clinics, Iowa City , Iowa , USA.
Ching-Jen ChenDepartment of Neurosurgery, The University of Texas Health Science Center at Houston, Houston , Texas , USA.
Jason P SheehanDepartment of Neurosurgery, University of Virginia Health System, Charlottesville , Virginia , USA.
Louis J KimDepartment of Neurosurgery, University of Washington, Seattle , Washington , USA.
Isaac Josh AbecassisDepartment of Neurosurgery, University of Washington, Seattle , Washington , USA.
Michael R LevittDepartment of Neurosurgery, University of Washington, Seattle , Washington , USA.
R Michael MeyerDepartment of Neurosurgery, University of Washington, Seattle , Washington , USA.
Ridhima GunigantiDepartment of Neurosurgery, Washington University School of Medicine in Saint Louis, St. Louis , Missouri , USA.
Akash P KansagraMallinckrodt Institute of Radiology, Washington University School of Medicine in Saint Louis, St. Louis , Missouri , USA.
Giuseppe LanzinoDepartment of Neurosurgery, Mayo Clinic Hospital, Rochester , Minnesota , USA.
Enrico GiordanDepartment of Neurosurgery, Mayo Clinic Hospital, Rochester , Minnesota , USA.
Waleed BrinjikjiDepartment of Radiology, Mayo Clinic Hospital, Rochester , Minnesota , USA.
Diederik O BultersDepartment of Neurosurgery, University Hospital Southampton, NHS Foundation Trust, Southampton , UK.
Andrew DurnfordDepartment of Neurosurgery, University Hospital Southampton, NHS Foundation Trust, Southampton , UK.
W Christopher FoxDepartment of Neurosurgery, Mayo Clinic, Jacksonville , Florida , USA.
Jessica SmithDepartment of Neurosurgery, University of Florida, Gainesville , Florida , USA.
Adam J PolifkaDepartment of Neurosurgery, University of Florida, Gainesville , Florida , USA.
Bradley GrossDepartment of Neurosurgery, University of Pittsburgh Medical Center Health System, Pittsburgh , Pennsylvania , USA.
Sepideh Amin-HanjaniDepartment of Neurosurgery, University of Illinois Chicago, Chicago , Illinois , USA.
Ali AlarajDepartment of Neurosurgery, University of Illinois Chicago, Chicago , Illinois , USA.
Amanda KwasnickiDepartment of Neurosurgery, University of Illinois Chicago, Chicago , Illinois , USA.
Robert M StarkeDepartment of Neurosurgery, University of Miami, Coral Gables , Florida , USA.
Stephanie H ChenDepartment of Neurosurgery, University of Miami, Coral Gables , Florida , USA.
J Marc C van DijkDepartment of Neurosurgery, University of Groningen, Groningen , Netherlands.
Adriaan R E PotgieserDepartment of Neurosurgery, University of Groningen, Groningen , Netherlands.
Junichiro SatomiDepartment of Neurosurgery, Tokushima University Hospital, Tokushima , Japan.
Yoshiteru TadaDepartment of Neurosurgery, Tokushima University Hospital, Tokushima , Japan.
Ryan PhelpsDepartment of Neurosurgery, University of California San Francisco, San Francisco , California , USA.
Adib AblaDepartment of Neurosurgery, University of California San Francisco, San Francisco , California , USA.
Ethan WinklerDepartment of Neurosurgery, University of California San Francisco, San Francisco , California , USA.
Rose DuDepartment of Neurosurgery, Brigham and Women's Hospital, Boston , Massachusetts , USA.
Pui Man Rosalind LaiDepartment of Neurosurgery, Brigham and Women's Hospital, Boston , Massachusetts , USA.
Santiago Ortega-GutierrezDepartment of Neurology, University of Iowa Hospitals and Clinics, Iowa City , Iowa , USA.
Gregory J ZipfelDepartment of Neurosurgery, Washington University School of Medicine in Saint Louis, St. Louis , Missouri , USA.
Colin DerdeynInstitute for Clinical and Translational Science, University of Iowa Hospitals and Clinics, Iowa City , Iowa , USA.
Edgar A SamaniegoDepartment of Neurology, University of Iowa Hospitals and Clinics, Iowa City , Iowa , USA.ORCID 0000-0003-2764-2268
University of Iowa Hospitals and Clinics · USUniversity of Washington · USMayo Clinic Hospital · USUniversity of California, San Francisco · USBrigham and Women's Hospital · USTokushima University Hospital · JPUniversity Hospital Southampton NHS Foundation Trust · GBUniversity of Florida · USUniversity of Groningen · NLUniversity of Illinois Chicago · USUniversity of Miami · USWashington University in St. Louis · USJacksonville College · USMallinckrodt (United States) · USThe University of Texas Health Science Center at Houston · USUniversity Hospitals of Cleveland · USUniversity of Virginia Health System · USUPMC Health System · US

Funding

WU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8M
Washington University Institute of Clinical and Translational SciencesUL1TR000448 · NCATS · WASHINGTON UNIVERSITY · PI EVANOFF, BRADLEY A · 2012 to 2016
$41.4M
The University of Iowa Clinical and Translational Science AwardUL1TR002537 · NCATS · UNIVERSITY OF IOWA · PI HANSEN, MARLAN R, WINOKUR, PATRICIA · 2018 to 2022
$20.0M
University of Iowa Institute for Clinical and Translational ScienceUM1TR004403 · NCATS · UNIVERSITY OF IOWA · PI Marlan R Hansen, Patricia Winokur · 2023 to 2026
$16.1M
Washington University Institute of Clinical and Translational SciencesTL1TR000449 · NCATS · WASHINGTON UNIVERSITY · PI EVANOFF, BRADLEY A · 2012 to 2016
$2.5M
NCATS NIH HHS TL1 TR000449NCATS NIH HHS UL1 TR000448NCATS NIH HHS UL1 TR002345NCATS NIH HHS UL1 TR002537NCATS NIH HHS UM1 TR004403NIH Blueprint for Neuroscience Research UM1TR004403
6 · The paper itself

Abstract

BACKGROUND AND

objectivesAnecdotal cases of rapidly progressing dementia in patients with dural arteriovenous fistulas (dAVFs) have been reported in small series. However, large series have not characterized these dAVFs. We conducted an analysis of the largest cohort of dAVFs presenting with cognitive impairment (dAVFs-CI), aiming to provide a detailed characterization of this subset of dAVFs.

methodsPatients with dAVFs-CI were analyzed from the CONDOR Consortium, a multicenter repository comprising 1077 dAVFs. A propensity score matching analysis was conducted to compare dAVFs-CI with Borden type II and type III dAVFs without cognitive impairment (controls). Logistic regression was used to identify angiographic characteristics specific to dAVFs-CI. Furthermore, post-treatment outcomes were analyzed.

resultsA total of 60 patients with dAVFs-CI and 60 control dAVFs were included. Outflow obstruction leading to venous hypertension was observed in all dAVFs-CI. Sinus stenosis was significantly associated with dAVFs-CI (OR 2.85, 95% CI: 1.16-7.55, P = .027). dAVFs-CI were more likely to have a higher number of arterial feeders (OR 1.56, 95% CI 1.22-2.05, P < .001) and draining veins (OR 2.05, 95% CI 1.05-4.46, P = .004). Venous ectasia increased the risk of dAVFs-CI (OR 2.38, 95% CI 1.13-5.11, P = .024). A trend toward achieving asymptomatic status at follow-up was observed in patients with successful closure of dAVFs (OR 2.86, 95% CI 0.85-9.56, P = .09).

conclusionVenous hypertension is a key angiographic feature of dAVFs-CI. Moreover, these fistulas present at a mean age of 58 years-old, and exhibit a complex angioarchitecture characterized by an increased number of arteriovenous connections and stenosed sinuses. The presence of venous ectasia further exacerbates the impaired drainage and contributes to the development of dAVFs-CI. Notably, in certain cases, closure of the dAVF has the potential to reverse symptoms.

Indexed as

DementiaFistulaIntervention

Identifiers

PMID38095434
PMCPMC12967309
OpenAlexW4389766875

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