Evidence map›Paper›PMID 38095282›Full record

ArticleDevelopment (Cambridge, England)2024

Postnatal persistence of hippocampal Cajal-Retzius cells has a crucial role in the establishment of the hippocampal circuit.

Ingvild Lynneberg Glærum, Keagan Dunville, Kristian Moan, Maike Krause, Nicola Pietro Montaldo, Hinako Kirikae, Maximiliano Jose Nigro, Pål Sætrom, Barbara van Loon, Giulia Quattrocolo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Development (Cambridge, England), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Partial Deletion ofeNeuro · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ingvild Lynneberg GlærumKavli Institute for Systems Neuroscience and Center for Algorithms of the Cortex, Norwegian University of Science and Technology (NTNU), Trondheim 7491, Norway.
Keagan DunvilleKavli Institute for Systems Neuroscience and Center for Algorithms of the Cortex, Norwegian University of Science and Technology (NTNU), Trondheim 7491, Norway.ORCID 0000-0001-9050-8278
Kristian MoanKavli Institute for Systems Neuroscience and Center for Algorithms of the Cortex, Norwegian University of Science and Technology (NTNU), Trondheim 7491, Norway.
Maike KrauseKavli Institute for Systems Neuroscience and Center for Algorithms of the Cortex, Norwegian University of Science and Technology (NTNU), Trondheim 7491, Norway.
Nicola Pietro MontaldoDepartment of Clinical and Molecular Medicine, Norwegian University of Science and Technology (NTNU), Trondheim 7491, Norway.
Hinako KirikaeKavli Institute for Systems Neuroscience and Center for Algorithms of the Cortex, Norwegian University of Science and Technology (NTNU), Trondheim 7491, Norway.
Maximiliano Jose NigroKavli Institute for Systems Neuroscience and Center for Algorithms of the Cortex, Norwegian University of Science and Technology (NTNU), Trondheim 7491, Norway.ORCID 0000-0001-6611-9125
Pål SætromDepartment of Clinical and Molecular Medicine, Norwegian University of Science and Technology (NTNU), Trondheim 7491, Norway.ORCID 0000-0001-8142-7441
Barbara van LoonDepartment of Clinical and Molecular Medicine, Norwegian University of Science and Technology (NTNU), Trondheim 7491, Norway.ORCID 0000-0002-7597-207X
Giulia QuattrocoloKavli Institute for Systems Neuroscience and Center for Algorithms of the Cortex, Norwegian University of Science and Technology (NTNU), Trondheim 7491, Norway.ORCID 0000-0001-6508-8910

Funding

324305H2020 Marie Skłodowska-Curie Actions; CaRe-Space 839988Norges Forskningsråd 324305NTNU: Norges teknisk-naturvitenskapelige universitetTrond Mohn stiftelse 2021TMT04
6 · The paper itself

Abstract

Cajal-Retzius (CR) cells are a transient neuron type that populate the postnatal hippocampus. To understand how the persistence of CR cells influences the maturation of hippocampal circuits, we combined a specific transgenic mouse line with viral vector injection to selectively ablate CR cells from the postnatal hippocampus. We observed layer-specific changes in the dendritic complexity and spine density of CA1 pyramidal cells. In addition, transcriptomic analysis highlighted significant changes in the expression of synapse-related genes across development. Finally, we were able to identify significant changes in the expression levels of latrophilin 2, a postsynaptic guidance molecule known for its role in the entorhinal-hippocampal connectivity. These findings were supported by changes in the synaptic proteomic content in CA1 stratum lacunosum-moleculare. Our results reveal a crucial role for CR cells in the establishment of the hippocampal network.

Indexed as

HippocampusProteomicsAnimalsMiceMice, TransgenicNeuronsPyramidal CellsCajal-Retzius cellsDevelopmentHippocampusSpines

Identifiers

PMID38095282
PMCPMC10820737

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.