Evidence map›Paper›PMID 38095068›Full record

ReviewCirculation2024

Current Status and Principles for the Treatment and Prevention of Diabetic Foot Ulcers in the Cardiovascular Patient Population: A Scientific Statement From the American Heart Association.

Katherine A Gallagher, Joseph L Mills, David G Armstrong, Michael S Conte, Robert S Kirsner, Samantha D Minc, Jorge Plutzky, Kevin W Southerland, Marjana Tomic-Canic, American Heart Association Council on Peripheral Vascular Disease; Council on Cardiovascular and Stroke Nursing; Council on Clinical Cardiology; and Council on Lifestyle and Cardiometabolic Health

Open access · bronzeAbstract readReview
In one paragraph

Review in Circulation, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed
13.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

59 citing papers in PubMed, 69 citations in OpenAlex.

  1. Article
  2. Article
  3. The Wound-Heart Axis: Can Chronic Wounds Contribute to Cardiac Dysfunction?International journal of molecular sciences · 2026
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  13. [Clinical characteristics and gender differences in Wagner grade 4-5 diabetic foot patients with variable severity of lower extremity atherosclerotic occlusive disease].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 3 countries.

Katherine A Gallagher
Joseph L Mills
David G Armstrong
Michael S Conte
Robert S Kirsner
Samantha D Minc
Jorge Plutzky
Kevin W Southerland
Marjana Tomic-Canic
American Heart Association Council on Peripheral Vascular Disease; Council on Cardiovascular and Stroke Nursing; Council on Clinical Cardiology; and Council on Lifestyle and Cardiometabolic Health
Centro Tecnológico del Mar · ESGallagher (United States) · USGeneral Mills (United States) · USSt Michael's Hospital · GBWardell Armstrong (United Kingdom) · GB

Funding

Regional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Martin G Myers · 2013 to 2026
$24.3M
Improving the science of adherence reinforcement and safe mobility in people with diabetic foot ulcers using smart offloadingR01DK124789 · NIDDK · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ARMSTRONG, DAVID GEORGE, NAJAFI, BIJAN · 2021 to 2025
$2.0M
Implementing a Community-Engaged Amputation Prevention Intervention in Rural Patients with Diabetes and Peripheral Arterial DiseaseK23DK128569 · NIDDK · WEST VIRGINIA UNIVERSITY · PI MINC, SAMANTHA D · 2021 to 2025
$977k
NIDDK NIH HHS K23 DK128569NIDDK NIH HHS P30 DK020572NIDDK NIH HHS R01 DK124789
6 · The paper itself

Abstract

Despite the known higher risk of cardiovascular disease in individuals with type 2 diabetes, the pathophysiology and optimal management of diabetic foot ulcers (DFUs), a leading complication associated with diabetes, is complex and continues to evolve. Complications of type 2 diabetes, such as DFUs, are a major cause of morbidity and mortality and the leading cause of major lower extremity amputation in the United States. There has recently been a strong focus on the prevention and early treatment of DFUs, leading to the development of multidisciplinary diabetic wound and amputation prevention clinics across the country. Mounting evidence has shown that, despite these efforts, amputations associated with DFUs continue to increase. Furthermore, due to increasing patient complexity of management secondary to comorbid conditions, such as cardiovascular disease, the management of peripheral artery disease associated with DFUs has become increasingly difficult, and care delivery is often episodic and fragmented. Although structured, process-specific approaches exist at individual institutions for the management of DFUs in the cardiovascular patient population, there is insufficient awareness of these principles in the general medicine communities. Furthermore, there is growing interest in better understanding the mechanistic underpinnings of DFUs to better define personalized medicine to improve outcomes. The goals of this scientific statement are to provide salient background information on the complex pathogenesis and current management of DFUs in cardiovascular patients, to guide therapeutic and preventive strategies and future research directions, and to inform public policy makers on health disparities and other barriers to improving and advancing care in this expanding patient population.

Indexed as

Cardiovascular DiseasesDiabetes Mellitus, Type 2Diabetic FootAmerican Heart AssociationHumansUnited StatesAHA Scientific Statementsamputation, surgicalcardiovascular diseasesdiabetes, type 2diabetic foothealth care disparitieshealth inequitiesperipheral arterial disease

Identifiers

PMID38095068
PMCPMC11067094
OpenAlexW4389742343

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.