ArticleiScience2024
Hippocampal cognitive and relational map paradigms explored by multisensory encoding recording with wide-field calcium imaging.
Article in iScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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Who cites it
6 citing papers in PubMed.
- Large-Scale Neural Recording Technologies for Investigating Circuit Dysfunction and Functional Biomarker Discovery in Animal Models of Alzheimer's Disease.International journal of molecular sciences · 2026Review
- Hippocampal criticality tracks cognitive demand and shifts with memory impairment.Communications biology · 2026Article
- Dissecting neuronal circuit function and dysfunction in Alzheimer's disease mouse models: from conventional calcium imaging analysis to machine learning-based approaches.Frontiers in aging neuroscience · 2026Review
- From microelectrode arrays to all-optical and multimodal neural interfaces: emerging platforms for spatiotemporal interrogation ofFrontiers in synaptic neuroscience · 2025Review
- Calcium Signalling in Neurological Disorders, with Insights from Miniature Fluorescence Microscopy.Cells · 2024Review
- Protocol for calcium imaging and analysis of hippocampal CA1 activity evoked by non-spatial stimuli.STAR protocols · 2024Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Two major theories have been proposed to explain hippocampal function: cognitive map and the relational theories. They differ in their views on whether hippocampal neurons can process non-spatial information independently. However, the explanatory power of these theories remains unresolved. Additionally, more complex aspects of hippocampal neural population responses to non-spatial stimuli have not been investigated. Here, we used miniaturized fluorescence microscopy to investigate mouse CA1 responses to spatial, visual, auditory modalities, and combinations. We found that while neuronal populations primarily processed spatial information, they also showed strong sensitivity to non-spatial modalities independent of spatial inputs, exhibiting distinct neuronal dynamics and coding patterns. These results provide strong support for the relational theories.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.