Evidence map›Paper›PMID 38094680›Full record

ArticleJACC. Basic to translational science2023

Decreased FAM13B Expression Increases Atrial Fibrillation Susceptibility by Regulating Sodium Current and Calcium Handling.

Gregory Tchou, Daniela Ponce-Balbuena, Nana Liu, Shamone Gore-Panter, Jeffrey Hsu, Fang Liu, Emmanuel Opoku, Gregory Brubaker, Sarah M Schumacher, Christine S Moravec and 4 more

Open access · goldAbstract read
In one paragraph

Article in JACC. Basic to translational science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. CommonCirculation. Genomic and precision medicine · 2024
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Gregory TchouDepartments of Cardiovascular and Metabolic Sciences, Cleveland Clinic, Cleveland, Ohio, USA.
Daniela Ponce-BalbuenaDepartment of Physiology and Cell Biology, Ohio State University, Columbus, Ohio, USA.
Nana LiuDepartments of Cardiovascular and Metabolic Sciences, Cleveland Clinic, Cleveland, Ohio, USA.
Shamone Gore-PanterDepartments of Cardiovascular and Metabolic Sciences, Cleveland Clinic, Cleveland, Ohio, USA.
Jeffrey HsuDepartments of Cardiovascular and Metabolic Sciences, Cleveland Clinic, Cleveland, Ohio, USA.
Fang LiuDepartments of Cardiovascular and Metabolic Sciences, Cleveland Clinic, Cleveland, Ohio, USA.
Emmanuel OpokuDepartments of Cardiovascular and Metabolic Sciences, Cleveland Clinic, Cleveland, Ohio, USA.
Gregory BrubakerDepartments of Cardiovascular and Metabolic Sciences, Cleveland Clinic, Cleveland, Ohio, USA.
Sarah M SchumacherDepartments of Cardiovascular and Metabolic Sciences, Cleveland Clinic, Cleveland, Ohio, USA.
Christine S MoravecDepartments of Cardiovascular and Metabolic Sciences, Cleveland Clinic, Cleveland, Ohio, USA.
John BarnardDepartment of Quantitative Health Sciences, Cleveland Clinic, Cleveland, Ohio, USA.
David R Van WagonerDepartments of Cardiovascular and Metabolic Sciences, Cleveland Clinic, Cleveland, Ohio, USA.
Mina K ChungDepartments of Cardiovascular and Metabolic Sciences, Cleveland Clinic, Cleveland, Ohio, USA.
Jonathan D SmithDepartments of Cardiovascular and Metabolic Sciences, Cleveland Clinic, Cleveland, Ohio, USA.
Cleveland Clinic · USThe Ohio State University · US

Funding

Clinical and Translational Science Collaborative of Northern Ohio, Catalyzing Linkages to Equity in Health (CLE Health)UM1TR004528 · NCATS · CASE WESTERN RESERVE UNIVERSITY · PI GRACE A MCCOMSEY · 2023 to 2026
$32.1M
Project 3 Genes to Omics-Informed Drugs: Drug Repositioning and Testing to Prevent AF ProgressionsP01HL158502 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI Mina Kay Chung · 2022 to 2026
$16.9M
RADIOMIC APPROACHES TO IMPROVE TARGETING FOR ATRIAL FIBRILLATION CATHETER ABLATIONR01HL158071 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI BARNARD, JOHN, CHUNG, MINA KAY · 2021 to 2024
$2.9M
BLRD VA IK6 BX006185NCATS NIH HHS UM1 TR004528NHLBI NIH HHS P01 HL158502NHLBI NIH HHS R01 HL158071
6 · The paper itself

Abstract

A specific genetic variant associated with atrial fibrillation risk, rs17171731, was identified as a regulatory variant responsible for controlling

Indexed as

CRISPR gene editingfunctional genomicspacing-induced arrhythmiaRho GTPase-activating protein

Identifiers

PMID38094680
PMCPMC10714175
OpenAlexW4385307445

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.