Evidence map›Paper›PMID 38094616›Full record

ArticlePNAS nexus2023

Type 2 diabetes impairs annulus fibrosus fiber deformation and rotation under disc compression in the University of California Davis type 2 diabetes mellitus (UCD-T2DM) rat model.

James L Rosenberg, Eric Schaible, Alan Bostrom, Ann A Lazar, James L Graham, Kimber L Stanhope, Robert O Ritchie, Tamara N Alliston, Jeffrey C Lotz, Peter J Havel and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PNAS nexus, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

James L RosenbergDepartments of Mechanical and Biomedical Engineering, University of Utah, Salt Lake City, UT 84112, USA.
Eric SchaibleAdvanced Light Source, Lawrence Berkeley Laboratory, Berkeley, CA 94720, USA.
Alan BostromDepartment of Epidemiology and Biostatistics, University of California, San Francisco, CA 94143, USA.
Ann A LazarDepartment of Epidemiology and Biostatistics, University of California, San Francisco, CA 94143, USA.
James L GrahamDepartment of Molecular Biosciences, University of California, Davis, CA 95616, USA.ORCID https://orcid.org/0000-0001-6507-8149
Kimber L StanhopeDepartment of Molecular Biosciences, University of California, Davis, CA 95616, USA.
Robert O RitchieMaterials Science Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.ORCID https://orcid.org/0000-0002-0501-6998
Tamara N AllistonDepartment of Orthopaedic Surgery, University of California, San Francisco, CA 94143, USA.ORCID https://orcid.org/0000-0001-9992-2897
Jeffrey C LotzDepartment of Orthopaedic Surgery, University of California, San Francisco, CA 94143, USA.
Peter J HavelDepartment of Molecular Biosciences, University of California, Davis, CA 95616, USA.
Claire AcevedoDepartments of Mechanical and Biomedical Engineering, University of Utah, Salt Lake City, UT 84112, USA.ORCID https://orcid.org/0000-0001-5425-3052
Aaron J FieldsDepartment of Orthopaedic Surgery, University of California, San Francisco, CA 94143, USA.ORCID https://orcid.org/0000-0001-6460-4506
University of California, San Francisco · USUniversity of California, Davis · USLawrence Berkeley National Laboratory · USUniversity of Utah · US

Funding

Role of the cartilage endplate in spinal disc degenerationR01AR070198 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FIELDS, AARON J · 2017 to 2021
$1.7M
NIAMS NIH HHS R01 AR070198
6 · The paper itself

Abstract

Understanding the biomechanical behavior of the intervertebral disc is crucial for studying disease mechanisms and developing tissue engineering strategies for managing disc degeneration. We used synchrotron small-angle X-ray scattering to investigate how changes to collagen behavior contribute to alterations in the disc's ability to resist compression. Coccygeal motion segments from 6-month-old lean Sprague-Dawley rats (

Indexed as

collagenintervertebral disclow back painsmall-angle X-ray scatteringtype 2 diabetes

Identifiers

PMID38094616
PMCPMC10718642
OpenAlexW4388479823

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.