Evidence map›Paper›PMID 38094499›Full record

ArticleFrontiers in veterinary science2023

Pharmacokinetics of cannabidiol-/cannabidiolic acid-rich hemp oil in juvenile cynomolgus macaques (

Tinika N Johns, Joseph J Wakshlag, Alexander V Lyubimov, Alexander Zakharov, Wesley M Burnside

Open access · goldAbstract read
In one paragraph

Article in Frontiers in veterinary science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Review
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  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Tinika N JohnsHaman Ranch, The Mannheimer Foundation, LaBelle, FL, United States.
Joseph J WakshlagDepartment of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY, United States.
Alexander V LyubimovToxicology Research Laboratory, Department of Pharmacology, College of Medicine, University of Illinois at Chicago, Chicago, IL, United States.
Alexander ZakharovToxicology Research Laboratory, Department of Pharmacology, College of Medicine, University of Illinois at Chicago, Chicago, IL, United States.
Wesley M BurnsideHaman Ranch, The Mannheimer Foundation, LaBelle, FL, United States.
University of Illinois Chicago · USNew York State College of Veterinary Medicine · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Cannabinoids are increasingly popular in human and veterinary medicine and have been studied as an alternative treatment for a wide range of disorders. The goal of this study was to perform a pharmacokinetic analysis of oral cannabidiol (CBD)-/cannabidiolic acid (CBDA)-rich hemp oil (CBD/ArHO) in juvenile cynomolgus macaques ( Methods: After a 2 mg/kg CBD/ArHO pilot study, 4 and 8 mg/kg direct-to-mouth CBD/ArHO were administered ( Results: The maximum mean serum concentration (C Discussion: Given the low serum CBD concentrations, the doses and frequency used in this study may be insufficient for a therapeutic effect of CBD in particular; therefore, clinical studies are needed to determine the therapeutic dose of CBD and CBDA for macaques, which may differ based on the disorder targeted.

Indexed as

cannabidiolcannabidiolic acidcannabinoidshemp (Cannabis sativa L.)monkeynoncompartmental analysisnonhuman primatepharmacokinetics

Identifiers

PMID38094499
PMCPMC10716325
OpenAlexW4389151599

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.